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Miller Lab - Immunology Research

Date Posted:
10/5/2017

Dermatology

MD

 Johns Hopkins University School of Medicine, Department of Dermatology

Name of the Investigator: Lloyd S. Miller, M.D., Ph.D., Associate Professor of Dermatology, Infectious Diseases and Orthopaedic Surgery

Description: Description: Full-time position for a Ph.D. or Ph.D. candidate is available for immunology research in the Johns Hopkins Department of Dermatology (in collaboration with the Johns Hopkins Division of Infectious Diseases) to investigate mechanisms of cutaneous host defense, Staphylococcus aureus and MRSA infections and inflammatory skin diseases such as atopic dermatitis and psoriasis. This research employs advanced techniques of in vivo optical and anatomical imaging and innovative human organotypic culture models of infection and humanized mice. Previous research experience in immunology research with experience in mouse models, cell culture, flow cytometry, ELISAs, and molecular biology techniques with with first-author peer-reviewed manuscripts in immunology is required. This is a unique opportunity for highly qualified and extremely motivated applicants to start their post-doctoral training in a newly renovated state-of-the-art research laboratory under the mentorship of Lloyd S. Miller, M.D., Ph.D.

For selected publications from the Miller Laboratory, please see:

Miller, LS and Cho, JS. 2011. Immunity against Staphylococcus aureus cutaneous infections. Nature Reviews Immunology 11(8): 505-518. http://www.nature.com/nri/journal/v11/n8/full/nri3010.html

Liu, H, Archer, NK, Dillen, CA, Wang, Y, Ashbaugh, AG, Ortines, RV, Kao, T, Lee, SK, Cai, SS, Miller, RJ, Marchitto, MC, Zhang, E, Riggins, DP, Plaut, RD, Stibitz, S, Geha, RS, Miller, LS. 2017. Staphylococcus aureus epicutaneous exposure drives skin inflammation via IL-36-induced IL-17-mediated T cell responses. Cell Host & Microbe. In press.

Cho, JS, Guo, Y, Ramos, RI, Hebroni, F, Plaisier, SB, Xuan, C, Granick, JL, Matsushima, H, Takashima, A, Iwakura, Y, Cheung, AL, Cheng, G, Lee, DJ, Simon, SI, Miller, LS. 2012. Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. PLOS Pathogens 8(11): e1003047. PMCID: PMC3510260. http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1003047

Cho, JS, Pietras, EM, Garcia, NC, Ramos, RI, Farzam, DM, Monroe, HR, Magorien, JE, Blauvelt, A, Kolls, JK, Cheung, AL, Cheng, G, Modlin, RL, Miller, LS. 2010. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. Journal of Clinical Investigation 120(5): 1762-1773. PMCID: PMC2860944. http://www.jci.org/articles/view/40891

Wang, Y, Cheng, LL, Helfer, DR, Ashbaugh, AG, Miller, RJ, Tzomides, AJ, Thompson, JM, Ortines, RV, Tsai, AS, Liu, H, Dillen, CA, Archer, NK, Cohen, TS, Tkaczyk, C, Stover, CK, Sellman, BR, Miller, LS. 2017. Hematogenous implant-related biofilm infection mouse model reveals therapeutic targets. Proceedings of the National Academy of Sciences USA 114(26):E5094-E5102: PMCID: PMC5495257. http://www.pnas.org/content/114/26/E5094

 

If interested, please send an email with your CV and contact information for 3 references to Dr. Lloyd Miller at: lloydmiller@jhmi.edu


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Singh Lab: Tissue Engineering and Regenerative medicine

Date Posted:
9/7/2017

James Buchanan Brady Urological Institute

MD

A Postdoctoral position is available at the Johns Hopkins University School of Medicine and the James Buchanan Brady Urological Institute within in the laboratory of Dr. Anirudha Singh, Ph.D. 

 The candidate is expected to focus on regeneration of urothelium, muscle layers, nerve and blood supplies.

 Extensive experience in tissue culture, cell and molecular biology, and imaging is required. Past research experiences in stem cells, scaffolds, organic/polymer chemistry, microscopy, spectroscopy methods (e.g. NMR, and FTIR) and biology is preferred. Applicants should be capable of independent experimental design and manuscript preparation, and have previously published high quality papers. An ideal candidate has an open mindset, and who is keen to learn, work and train in a highly collaborative environment, and have strong communication skills and a positive mindset.

 Please submit an application including a cover letter and CV that describe your research potentials, accomplishments and interests to Dr. Singh at asingh29@jhu.edu .


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Margolis Lab: Molecular Neurobiology, Huntington's Disease

Date Posted:
8/25/2017

Department of Psychiatry

MD

Our laboratory is interested in the identification and characterization of therapeutic targets for the treatment of Huntington’s disease (HD) and related disorders.  As part of this effort, we have received funding to explore the molecular biology of huntingtin, the HD gene, with an emphasis on the mechanisms that regulate its expression and on searching for small molecules that may treat HD by decreasing expression of huntingtin.  We are seeking a post-doc to take a leading role in this project.  In particular, strong candidates will have extensive experience in mechanisms of gene regulation and a long-term career interest in neurodegenerative or neuropsychiatric disorders. 

 If interested, please send a letter describing your experience and interests, with an attached CV, to rmargoli@jhmi.edu, office phone 410-614-4262


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Richard Rothman Lab - ED Influenza Therapeutic Pilot Research Study

Date Posted:
8/4/2017

Department of Emergency Medicine

MD

The Postdoctoral Fellow will contribute to the research activities conducted as part of various projects by providing substantial and important recommendations to the design and methodologies used by these studies and by taking primary responsibility for data collection, analysis, interpretation, reporting on the findings from these studies, and writing manuscripts and publications.

The Postdoctoral Fellow will require specialized advanced knowledge, education and/or training in statistical analyses and/or qualitative research methods.  Develop detailed data collection and analysis methodologies, including defining in detail data requirements, data sources and proper data collection procedures (e.g., computer programs, appropriate data fields, databases, and sample size calculations.)

Develop and implement data collection quality assurance procedures to ensure the validity and reliability of the study results.  Be responsible for data collection and data cleaning activities including in certain cases data entry from electronic medical records, quality assurance (qa)/quality control (qc), and supervising locally hired staff to perform data collection and qa/qc using appropriate methods (e.g., clinical data report forms, surveys, laboratory data, questionnaires, experiments, gathering data from available sources).  Some skills in handling and interpreting laboratory based data is considered advantageous, as is skill in inter-facing with laboratory personnel, for purposes of data analysis related to laboratory specimen repository evaluations.

Using their knowledge of statistical and textual data analysis, perform quantitative and qualitative data analysis and interpretation of study data.  Write reports, and generate charts, tables, figure, and presentations of the research findings for dissemination (posters, talks, manuscripts).  Conduct literature reviews and summarize findings.  Serve as resource for research staff and field data research coordinators regarding data issues, collection, entry, quality and transfer.  Will primarily be the lead in writing of manuscripts and publications; strong writing skills highly important.  Present research findings at meetings and conferences.

Qualifications: Doctoral degree in Public Health, Epidemiology, Biostatistics, Bioinformatics, Statistics, Psychology, or related field required.  Three years of related experience preferred.

Experience in managing large datasets and using at least one or several analytic software such as SAS, SPSS, or Stata required.  Strong writing skills and track record with writing and editing manuscripts (and/or grant applications) is a plus.

Applicant must have strong interpersonal skills and ability to work as part of a multi-disciplinary team, while contributing to a high quality and respectful work environment.  Strong oral and written communication skills, with the ability to communicate effectively to colleagues and staff across multi-disciplinary areas.  Ability to manage multiple projects in a dynamic environment with changing priorities.  Proven ability to establish realistic goals and deliver work on schedule. Ability to work independently and solve problems as they arise and communicate effectively with staff, colleagues, co-investigators, and principal investigator.

Please send all applications to Dr. Richard Rothman - rrothma1@jhmi.edu and Ms. Erin Ricketts – ericket2@jhmi.edu

 

 


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