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Kohr Lab - Cardiovascular Redox Signaling

Date Posted:
2/19/2018

Environmental Health and Engineering (School of Public Health)

MD

The Kohr Laboratory of Cardiovascular Redox Signaling has an immediate opening for a
postdoctoral fellow position. This is an excellent opportunity to join an exciting, NIH-funded
research team focused on demystifying sex-specific, redox-dependent differences in the heart’s
response to ischemic injury with the ultimate goal of identifying novel, cardioprotective signaling
pathways. The role of protein S-nitrosation in the female heart, which is naturally protected from
ischemic injury, is a major focus of current studies. We have developed a number of cutting-edge
mass spectrometry-based proteomic methodologies to map sites of S-nitrosation and other
redox-based modifications, and we use these in tandem with cellular, molecular, and biochemical
methods to assess the effects of S-nitrosation on the function, stability, and localization of
specific protein targets. We also utilize a number of physiological approaches to evaluate
myocardial function, including the Langendorff-perfused heart preparation, in vivo pressurevolume
loop analysis, and echocardiography. Our lab primarily utilizes cell and mouse-based
models for experimentation. By defining female-specific and other protective signaling pathways
in the heart, we are working to identify key therapeutic targets for the treatment of ischemic
heart disease in both men and women.
We are seeking a creative scientist to pursue independent and collaborative research within the
Bloomberg School of Public Health and the School of Medicine at Johns Hopkins University. State
of the art facilities and excellent core laboratories are available for research projects. The
applicant should possess a PhD, MD, or equivalent. Preferred qualifications include experience
in heart physiology, proteomics and/or redox biology. Interested applicants should send a cover
letter and a curriculum vitae including publications in PDF format to: mkohr1@jhu.edu.


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Orthopaedic Outcomes and Rehabilitation Research

Date Posted:
1/30/2018

Departments of Orthopaedics, Physical Medicine & Rehabilitation, Health Policy and Management

MD

The Johns Hopkins Department of Orthopaedics, in collaboration with the Department of Physical Medicine and Rehabilitation and the Department of Health Policy and Management in the Bloomberg School of Public Health is looking for recent doctoral graduates interested in a post-doctoral position in orthopaedic and rehabilitation outcomes research. This position is supported by the NIH Training in Orthopaedic Team Science (TOTS) program which is designed to provide a focused training experience in translational science related to improving the diagnosis, management and outcomes of musculoskeletal conditions and injuries. The successful candidate will work with a team of scientists in orthopaedics and the Major Extremity Trauma and Rehabilitation Consortium (METRC). METRC is a research consortium funded by the Department of Defense and consists of over 50 trauma centers and military treatment centers dedicated to producing the evidence needed to ensure quality outcomes for service members and civilians who sustain orthopaedic trauma.

Application is open to candidates who have the following:
- A PhD or other advanced research degree in physical or occupational therapy, rehabilitation psychology, health services research, rehabilitation sciences, epidemiology, or other related field
- A strong commitment to ‘team science’ and translational research
- A commitment to a career focused on clinical investigation of orthopaedic conditions and injuries
- U.S. citizenship, non-citizen national status, or permanent residency


Candidates interested in this program are asked to provide a current curriculum vitae and a personal statement that addresses:
- Background information relevant to the candidate’s interest in the clinical research in orthopaedics;
- Long-term career goals and how the TOTS Program can facilitate advancement towards these goals;
- Summary of prior or ongoing research interests.

Please send inquiries to:
Dr. Ellen J. MacKenzie
Dean and Bloomberg Distinguished Professor of Health Policy and Management, Orthopaedic Surgery and Physical Medicine and Rehabilitation
Director of the Major Extremity Trauma and Rehabilitation Consortium
Johns Hopkins Bloomberg School of Public Health
615 North Wolfe Street
Baltimore, MD 21205
emacken1@jhu.edu


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Kegan Lab – Vascular cell biology and lung physiology

Date Posted:
12/19/2017

Anesthesiology and Critical Care Medicine

MD

Dr. Kazuyo Kegan, Ph.D., at the Johns Hopkins University School of Medicine, Department of Anesthesiology and Critical Care Medicine, is seeking qualified applicants for postdoctoral fellowship positions. The overall focus of the Kegan lab is to understand the mechanisms, regulation, and functional outcomes of immune responses in the pulmonary vasculature during the development of pulmonary hypertension.

Postdoctoral fellow(s) will work on projects to determine how aberrant immune and inflammatory responses in the pulmonary vasculature, particularly those caused by activated macrophages, develop and contribute to the evolution of vascular remodeling and right heart failure. To elucidate these mechanisms, fellows will use in vivo animal models, genetically modified animals, in vitro cell biology, immunohistochemistry, and genetic and biochemical approaches.

A successful candidate will use basic science approaches to address clinically relevant issues within a multidisciplinary team that includes clinician scientists and biomedical engineering groups. In addition, he/she will have opportunities to use cutting-edge techniques such as sophisticated live cell imaging, highly specialized techniques for isolation and culture of primary cells in vitro, and analysis of pulmonary vascular physiology and/or hemodynamics in vivo.

Candidates should have a recent PhD degree (or equivalent) with a background in physiology, cell and molecular biology, biomedical science, or pharmacology. A strong publication record is also recommended. Individuals with experience in vascular/macrophage biology, immunology, or animal studies will be given preference. We value self-motivated, enthusiastic, and collaborative team members. Salary follows the NIH standard and is commensurate with qualifications and experience.

Interested individuals should submit a cover letter (1-2 pages) containing a summary of their prior work, research interests, and career goal along with a CV and information for 3 references as a single pdf to Dr. Kegan at kkegan1@jhmi.edu.


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Effects of small molecular therapeutics on gene expression in human cancers

Date Posted:
12/18/2017

Johns Hopkins Kimmel Comprehensive Cancer Center

MD

Postdoctoral positions available at the Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore, MD.

 

Two Postdoctoral Positions available immediately for highly motivated candidates with exceptionally strong background in molecular and cellular biology. Knowledge and experience in analyses of transcription regulation, chromatin modification, and mouse tumor models required. Projects will focus on mechanistic studies on small molecule cancer therapeutics and their genomic and transcriptomic analyses in human cancers.

 

The applicants should have a Ph.D. or M.D. Ph.D. degree, demonstrated relevant research experience and publication record, and strong work ethic. Excellent verbal and written English communication skills are essential.

 

Please send curriculum vitae, a cover letter stating research interests and career goals, and names and contact information of three references in a single pdf file to:

 

Dr. Marikki Laiho, M.D. Ph.D., Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287.

E-mail: mlaiho1@jhmi.edu

 

Closing date for applications January 15, 2018.

 

The John Hopkins University School of Medicine is an Affirmative Action / Equal Opportunity Employer that embraces diversity.


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