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4 Job(s) found.

Nimmagadda Lab: Cancer Immunotherapy and Imaging

Date Posted:
11/7/2019

Radiology

MD

We have an opening for a highly motivated post-doctoral fellow to characterize tumor response to immunotherapy in the Division of Nuclear Medicine at the Johns Hopkins University School of Medicine. We are a highly collaborative multi-disciplinary group that loves to develop novel tools for non-invasive visualization and quantification of biological processes in vivo. For recent research please refer to:

  • J Clin Invest. 2019 Feb 1;129(2):616-630;
  • Biochem Biophys Res Commun. 2017 Jan 29;483(1):258-263;
  • Oncotarget. 2016 Mar 1;7(9):10215-27.

 Competitive applicants will possess: a Ph.D. or M.D. degree in biological sciences or a related field with <2 years of post-doc experience and a strong publication record.  Prior background in cancer biology, pharmacology, or immunology is preferred but not essential.   Prior experience with mouse models is highly desired. Candidates should be comfortable in handling radioactive materials.  Ability to work independently as well as in a team environment towards timely execution of projects is needed. For immediate consideration, submit your CV, statement of research interests and names of three references with contact information to:  Dr. Sridhar Nimmagadda, Associate Professor, Department of Radiology, Johns Hopkins University School of Medicine, 1550 Orleans Street, #492, Cancer Research Building-II, Baltimore, MD 21287. Fax: (410) 314-6147.  E-mail: snimmag1@jhmi.edu.

JHU is Equal Opportunity Employer. Minorities/Women/Protected Veterans/Disabled are encouraged to apply.


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Tampakakis Lab: Developmental Cardiology and Stem Cell Biology Lab

Date Posted:
9/19/2019

Department of Medicine; Division of Cardiology

MD

A Developmental Cardiology and Stem Cell Biology lab at Johns Hopkins School of Medicine is looking for talented post-doc students to join the lab of Dr. Emmanouil Tampakakis. Our group uses cutting edge methods for single-cell transcriptomics, flow cytometry, gene editing, and single cardiomyocyte mechanics. Our research is innovative and aims to: 1) investigate the molecular pathways of cardiomyocyte maturation, 2) develop and optimize new methods for heart regeneration, 3) study the role of cardiac innervation during heart development, and 4) use stem cell-derived cardiomyocytes to model inherited heart diseases.

 Strong funding history, close mentorship, collaborative science, a recently renovated laboratory, and strong core facilities provide an outstanding research environment. The candidate must be self-motivated, ambitious, hard-working, and have a solid background in standard molecular and biological techniques, cell culture and, ideally, mouse models. Previous experience in stem cell and computational biology is preferred but not required. The position requires the ability to lead projects, work cooperatively with others and carry out and troubleshoot experiments.

 Please email a letter of application, curriculum vitae, and names of three references to Emmanouil Tampakakis MD, Assistant Professor of Medicine, Division of Cardiology, Johns Hopkins School of Medicine at etampak1@jhmi.edu.


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Avramopoulos Lab: Schizophrenia Disease Variants in iPS Cells with CRISPR/Cas9

Date Posted:
9/18/2019

Department of Genetic Medicine

MD

The lab of Dimitri Avramopoulos, studying schizophrenia in the Department of Genetic Medicine, is looking for a postdoctoral research fellow to work on a project introducing disease variants into human induced pluripotent stem cells by CRISPR/Cas9 genome editing, stimulating neuronal differentiation and studying the resulting transcriptomic changes and cellular phenotypes. This is a highly collaborative laboratory currently consisting of 2 graduate students, 2 postdocs and a research technologist. The candidate must have previously worked in a molecular biology or related laboratory and it is preferred that the candidate has some experience in mammalian cell culture.

 

The Department of Genetic Medicine offers an academically stimulating environment with 17 laboratories occupying 2 floors in the Miller Research Building and sharing an array of common large equipment. The new fellow can participate in an array of academic activities such as our weekly journal club, a monthly science and pizza forum where students of all levels can present their work and a genetics seminar with invited guest lectures from across the country. The Avramopoulos lab is also a member of the Johns Hopkins Schizophrenia Center, a collaboration of multiple PIs from Genetics, Psychiatry, the Kennedy Krieger Institute and the Lieber Institute, with monthly meetings open to all lab members that can be instrumental in widening their knowledge base and networking. Postdocs can also seek career and professional development training through the Johns Hopkins Professional Development and Career Office.

 

Interested candidates should submit their CV and a statement of career interests to Dr. Dimitri Avramopoulos at adimitr1@jhmi.edu.


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Borahay Lab: Reproductive Science Research

Date Posted:
8/22/2019

Gynecology and Obstetrics

MD

This position is for a highly motivated postdoctoral research fellow to work on an exciting project in reproductive science at Johns Hopkins University at Baltimore, MD. The PI is Dr. Mostafa Borahay, MD, PhD and the project includes building a model for uterus with the three cellular layers, muscle, stroma and epithelium using bioengineering. In addition, the fellow will also work on an exciting ongoing project examining statins as a new treatment for uterine leiomyomas, the most common tumor of female reproductive system. Understanding the underlying pathogenesis of the tumor is another goal. Johns Hopkins University, the institution #1 in NIH funding for more than 30 years, provide an outstanding environment for state-of-the-art research for an ambitious fellow. The work will include cellular and extracellular matrix experiments of cell cultures (both conventional and 3D) from primary & immortalized cells. It will also include tissues obtained from patients and animal models. In addition to standard cell culture, molecular biology, and histologic techniques, work will include experiments on stem cells and epigenetics. Work is funded by NIH grant and candidates for this position are expected to conduct research work in the current grant and preparation to apply for NIH funding. The fellow is expected to be self-motivated, organized, and team player.

Responsibilities:

  • Critically review available literature and design research work accordingly.
  • Plans, conducts, and troubleshoots experiments.
  • Performs data analysis, prepares graphical representation of data, prepares manuscripts for publication in peer reviewed scientific journals, assists in the preparation of scientific reports for funded projects, presents research data at in-house meetings and at National and International scientific conferences.
  • Participates in preparation of applications for funding.
  • Participates on scientific collaborations both within and outside the institution as discussed with the PI.
  • Adopts technologies and protocols currently used in the lab and be able to research, find, and learn additional ones necessary for the work
  • Works as a team member with other faculty members, clinical research team, fellows, residents, and students.
  • Attends training and safety classes required by JHU
  • Completes other projects and duties as assigned.
  • Accurately documents experiments and results and keeps a detailed laboratory note.
  • Possesses good oral and written communication skills
  • Able to prioritize workload and manage multiple projects effectively.

 Required Knowledge, Skills, and Abilities:

Knowledge of complex scientific procedures and techniques; knowledge and practical experience in biophysical techniques, fundamental molecular and cellular biology and familiarity with biochemistry and cell culture, proliferation, cell death, protein science, Western Blotting, flow cytometry, RNA, DNA, sequencing, epigenetic (DNA methylation and histone modification) techniques. Candidate is expected to learn new techniques as necessary. Candidate is expected to demonstrate successful publication of doctoral work in reputable journals. Prior successful funding during doctoral work is a plus.

Training and Career Development plan

This postdoctoral research fellowship program is designed to prepare the fellow for independent academic career in reproductive research. Focus will be scientific productivity demonstrated by innovative research, publication in high impact journals and successful extramural funding. Fellow is expected to transition in few years into an independent faculty role.

Education: Ph.D. in Cell Biology or Molecular Biology

Work Environment: Laboratory environment; requires working with human and animal cells/cell lines, blood, and or bodily fluids

Supervisory Responsibilities/Controls: May provide guidance to laboratory staff and train junior staff members.

Department/Division: Johns Hopkins University, School of Medicine, Department of Gynecology and Obstetrics. Division of Division of Reproductive Science and Women’s Health Research.

Women and Minorities are highly encouraged to apply. Johns Hopkins University is an equal opportunity employer.

To apply: Send CV including references and a cover letter/personal statement to PI: Mostafa Borahay, MD, PhD. Email: mboraha1@jhmi.edu


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