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Perera Lab: Cell & Molecular Biology (Oncology and Non-Coding RNA)

Date Posted:
2/25/2020

All Childrens Hospital, Center for RNA Biology

FL

A postdoctoral fellow position is open immediately in Dr. Ranjan J. Perera’s laboratory at the Department of Oncology, Johns Hopkins University School of Medicine and Center for RNA Biology, Johns Hopkins All Children’s Hospital.  The Perera laboratory is employing a combination of biochemical, genetic, genomic and functional genomic approaches to study the biogenesis mechanism of regulatory non-coding RNAs, and to elucidate their function in tumor formation. Several putative oncogenic and tumor suppressor non-coding RNAs have been identified ( Lee et al. Science Advances 2017 3(5): e1602505, Mazar et al. Mol. Cell. Biol. 2016, Wei et al., JID 2016) and will characterize these through in-vitro and in-vivo functional and analytical genomics and single cell sequencing assays to connect them to cancer metabolism and epigenome.

Required Experience:

The Ph.D. and/or M.D.  Cancer Cell Biology candidate must have a strong background in at least one of the following areas: tumor biology, cell biology, molecular biology, transcriptional/post-transcriptional gene regulation. Experience in vivo mouse studies is an advantage. Perera laboratory will be a part of the Center for RNA Biology in the new research institute at the Johns Hopkins All Children’s Hospital.This position is open until a suitable candidate is identified. Salary and fringe benefits will be very compliant with guidelines established by the Johns Hopkins University School of Medicine. Interested candidates, please send CV and relevant publications to Dr. Ranjan J. Perera at jperera2@jhmi.edu


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Perera Lab: Bioinformatics (Oncology & Non-coding RNA)

Date Posted:
2/25/2020

All Childrens Hospital, Center for RNA Biology

FL

Job Description

A postdoctoral fellow position (Bioinformatics) is available to study the role of non-coding RNAs in cancer (long noncoding RNA, microRNAs, Circular RNA, and Super Enhancers) in our laboratory at the Johns Hopkins University All Children Hospital Campus USA.  Several putative oncogenic and tumor suppressor non-coding RNAs been identified (Lee et al Science Advances 2017 3(5): e1602505, Mazar et al Mol. Cell. Biol. 2016, Wei et al., JID 2016) and will characterize these through in-vitro and in-vivo functional and analytical genomics and single cell sequencing assays to connect them to cancer metabolism and epigenome.  The post-doctoral candidate will work on sequence analysis for detection of lncRNA-DNA triple helices, lncRNA-protein interaction, lncRNA epigenetic gene regulation and single cell sequencing.

 Required Experience:

Applicant should hold a Ph.D. in Bioinformatics or Computer Science. Experience in the analysis of biological sequences and regulatory genomics is required. The candidate should have solid programming skills (C, Python and/or R) and acquaintance with Unix/Linux. Experience with high performance computing is a plus. The position is a full time position to be filled as soon as possible.

Perera laboratory will be a part of the Center for RNA Biology in the new research institute at the Johns Hopkins All Children’s Hospital in St. Petersburg, Florida, which is known for its pleasant weather, low cost of living and beautiful beaches. This position is open until a suitable candidate is identified. Salary and fringe benefits will be very compliant with guidelines established by the Johns Hopkins University School of Medicine. Interested candidates, please send CV and relevant publications to Dr. Ranjan J. Perera at jperera2@jhmi.edu


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Tampakakis Lab: Developmental Cardiology and Stem Cell Biology Lab

Date Posted:
2/25/2020

Department of Medicine; Division of Cardiology

MD

A Developmental Cardiology and Stem Cell Biology lab at Johns Hopkins School of Medicine is looking for talented post-doc students to join the lab of Dr. Emmanouil Tampakakis. Our group uses cutting edge methods for single-cell transcriptomics, flow cytometry, gene editing, and single cardiomyocyte mechanics. Our research is innovative and aims to: 1) investigate the molecular pathways of cardiomyocyte maturation, 2) develop and optimize new methods for heart regeneration, 3) study the role of cardiac innervation during heart development, and 4) use stem cell-derived cardiomyocytes to model inherited heart diseases.

 Strong funding history, close mentorship, collaborative science, a recently renovated laboratory, and strong core facilities provide an outstanding research environment.

The candidate must be self-motivated, ambitious, hard-working, and have a solid background in standard molecular and biological techniques, cell culture and, ideally, mouse models. Previous experience in stem cell and computational biology is preferred but not required. The position requires the ability to lead projects, work cooperatively with others and carry out and troubleshoot experiments.

 Please email a letter of application, curriculum vitae, and names of three references to Emmanouil Tampakakis MD, Assistant Professor of Medicine, Division of Cardiology, Johns Hopkins School of Medicine. etampak1@jhmi.edu

 


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Optimizing Therapy in Tuberculous Meningitis

Date Posted:
2/4/2020

Department of Anesthesiology and Critical Care Medicine

MD

Description: A postdoctoral fellow position is available in the Department of Anesthesiology and Critical Care Medicine at Johns Hopkins University School of Medicine. We are looking for qualified persons with interest and experience in working with animal models, to join a multidisciplinary group working in the cutting-edge area of exploring noninvasive imaging, host-directed therapy and nanoparticles to optimize treatment in a pediatric rabbit model of tuberculous meningitis. This work will be part of a Hartwell Foundation - Individual Biomedical Research Award funded project to optimize tuberculous meningitis treatment by using host-targeted theranostic nanoparticles to monitor and treat meningitis in the rabbit model. As a postdoctoral fellow, the candidate will develop an Individual Development Plan (IDP) and receive career mentorship from a scholarship oversight committee that will meet regularly. The postdoctoral fellow will be eligible to apply for fellowship grants, and have access to departmental and institutional career development programs, such as grant writing workshops.

The candidate should have an interest in immunology/neuroscience, infectious disease pathogenesis (Tuberculosis), pharmacokinetics, nanoparticle drug delivery or other related fields. Research experience in any of these areas are highly desired but not required: (1) processing and handling of brain tissue, (2) tissue sectioning and immunohistochemistry, (3) basic microscopy or confocal imaging, (4) RT-PCR/Western Blots/ELISAs, (5) animal handling and behavior evaluation, (6) bacterial handling and culture, (7) flow cytometry, (8) pharmacokinetic basics, or (9) proficiency with statistical software. The candidate should be highly motivated, with good communication and writing skills and should be able to interact well with other members of the multidisciplinary team. The position is available immediately and salary will be commensurate with experience. Please submit your CV as well as a statement of interest with long-term career plans.

Contact Information | Interested candidates are encouraged to contact Elizabeth Tucker, MD, Assistant Professor, Anesthesiology and Critical Care Medicine, Johns Hopkins University SOM via email: etucker9@jhmi.edu

 JHU is an equal opportunity employer. Applications from minorities and women are especially encouraged.


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