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Small Lab - Role of FLT3 in development and prognosis of leukemia

Date Posted:
11/3/2017

Oncology

MD

The Small lab in the Oncology Department at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins has an opening for a postdoctoral fellow. The lab’s research is focused on understanding the role of FLT3, one of the most frequently mutated genes in AML, in the development and prognosis of leukemia. This includes studies of cooperativity with other genetic alterations and how to target these pathways to generate improved therapies for patients with AML. The lab’s interests extend from the study of signal transduction to the generation of genetically engineered murine models to drug development.

 Qualified candidates must have a recent PhD degree with a record of publications in the relevant field of study. Highly self-motivated candidates with a strong background in molecular/cellular biology are encouraged to apply. The successful candidate will be fully trained in cellular / molecular medicine and hematology / oncology with proficiency in oral presentation and grant / manuscript preparation.  

 The Johns Hopkins University is an Equal Opportunity / Affirmative Action Employer. To apply, please email your CV with a cover letter summarizing your experience and the contact information of three references to:

 

Donald Small, M.D., Ph.D. 

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 

CRB1 Room 251, 1650 Orleans St. Baltimore, MD 21231 

Phone: 410-614-0994;  e-mail: donsmall@jhmi.edu 

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Miller Lab - Immunology Research

Date Posted:
10/5/2017

Dermatology

MD

 Johns Hopkins University School of Medicine, Department of Dermatology

Name of the Investigator: Lloyd S. Miller, M.D., Ph.D., Associate Professor of Dermatology, Infectious Diseases and Orthopaedic Surgery

Description: Description: Full-time position for a Ph.D. or Ph.D. candidate is available for immunology research in the Johns Hopkins Department of Dermatology (in collaboration with the Johns Hopkins Division of Infectious Diseases) to investigate mechanisms of cutaneous host defense, Staphylococcus aureus and MRSA infections and inflammatory skin diseases such as atopic dermatitis and psoriasis. This research employs advanced techniques of in vivo optical and anatomical imaging and innovative human organotypic culture models of infection and humanized mice. Previous research experience in immunology research with experience in mouse models, cell culture, flow cytometry, ELISAs, and molecular biology techniques with with first-author peer-reviewed manuscripts in immunology is required. This is a unique opportunity for highly qualified and extremely motivated applicants to start their post-doctoral training in a newly renovated state-of-the-art research laboratory under the mentorship of Lloyd S. Miller, M.D., Ph.D.

For selected publications from the Miller Laboratory, please see:

Miller, LS and Cho, JS. 2011. Immunity against Staphylococcus aureus cutaneous infections. Nature Reviews Immunology 11(8): 505-518. http://www.nature.com/nri/journal/v11/n8/full/nri3010.html

Liu, H, Archer, NK, Dillen, CA, Wang, Y, Ashbaugh, AG, Ortines, RV, Kao, T, Lee, SK, Cai, SS, Miller, RJ, Marchitto, MC, Zhang, E, Riggins, DP, Plaut, RD, Stibitz, S, Geha, RS, Miller, LS. 2017. Staphylococcus aureus epicutaneous exposure drives skin inflammation via IL-36-induced IL-17-mediated T cell responses. Cell Host & Microbe. In press.

Cho, JS, Guo, Y, Ramos, RI, Hebroni, F, Plaisier, SB, Xuan, C, Granick, JL, Matsushima, H, Takashima, A, Iwakura, Y, Cheung, AL, Cheng, G, Lee, DJ, Simon, SI, Miller, LS. 2012. Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. PLOS Pathogens 8(11): e1003047. PMCID: PMC3510260. http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1003047

Cho, JS, Pietras, EM, Garcia, NC, Ramos, RI, Farzam, DM, Monroe, HR, Magorien, JE, Blauvelt, A, Kolls, JK, Cheung, AL, Cheng, G, Modlin, RL, Miller, LS. 2010. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. Journal of Clinical Investigation 120(5): 1762-1773. PMCID: PMC2860944. http://www.jci.org/articles/view/40891

Wang, Y, Cheng, LL, Helfer, DR, Ashbaugh, AG, Miller, RJ, Tzomides, AJ, Thompson, JM, Ortines, RV, Tsai, AS, Liu, H, Dillen, CA, Archer, NK, Cohen, TS, Tkaczyk, C, Stover, CK, Sellman, BR, Miller, LS. 2017. Hematogenous implant-related biofilm infection mouse model reveals therapeutic targets. Proceedings of the National Academy of Sciences USA 114(26):E5094-E5102: PMCID: PMC5495257. http://www.pnas.org/content/114/26/E5094

 

If interested, please send an email with your CV and contact information for 3 references to Dr. Lloyd Miller at: lloydmiller@jhmi.edu


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