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Maheshwari Lab - Computational Genomics of Necrotizing Enterocolitis

Date Posted:
7/18/2018

Pediatrics

MD

A postdoctoral fellowship/research scientist position is available at Maheshwari laboratory of the Charlotte R. Bloomberg Children’s Center, Johns Hopkins University, Baltimore, MD. The individual will lead integrative computational genomics initiatives to characterize the mammalian genomic landscape and the enteric microbiome during necrotizing enterocolitis, which is an inflammatory bowel necrosis of premature infants. The candidate will also participate in the development of novel animal models to investigate neonatal intestinal injury. He/she will receive multidisciplinary training in or will be an active participant in projects combining computational genomics, integrative bioinformatics, molecular biology, and translational research. The candidate must hold a Ph.D. degree in the Biomedical Sciences or an advanced degree in bioinformatics. Preference will be given to highly-motivated candidates with an outstanding publication record in bioinformatics-based research, and those with established expertise in computational genomics, bioinformatics, or biostatistics.

The candidate will perform integrative analysis of deep-sequencing datasets of mammalian cells and 16S rRNA-based or whole genome sequencing for the gut microbiome. He/she will collaborate with other lab members who are focused on the development of animal and cellular models, and will also have opportunities to teach medical and bioscience trainees at various levels who might rotate through the lab.

Maheshwari laboratory is a translational research lab in the Department of Pediatrics at Johns Hopkins University, Baltimore. For more information, please send your CV, cover letter, and the contact information of 3 referees to:

 Akhil Maheshwari, M.D.

Professor of Pediatrics, PAR
?Director, Eudowood Division of Neonatology
?Vice-Chair (Integration), Department of Pediatrics
?Johns Hopkins University School of Medicine
??Office: The Charlotte R. Bloomberg Children’s Center / Room 8530
?   1800 Orleans Street
?   Baltimore, Maryland 21287
?   Email: akhil@jhmi.edu; Phone: 410-955-4574; Fax 410-955-0298


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Post Doctoral Researcher in Biochemistry or Pharmacology

Date Posted:
6/7/2018

Drexel University College of Medicine

PA

Post Doctoral Researcher  
3630  
A postdoctoral position is immediately available in the Sato laboratory, at Drexel University College of Medicine to study G-Protein Coupled Receptor (GPCR) signaling in the pancreas-heart cross-talk. The Sato laboratory is located in the Department of Pharmacology and Physiology. We have access to state-of-the-art resources for metabolic studies, bioimaging and cardiovascular research.
We seek to hire an outstanding experimentalist with a Ph.D. in biochemistry, pharmacology or equivalent, and demonstrated experience in cell signaling and molecular cloning. Knowledge of biochemical methodologies, immunohistochemistry, echocardiography, metabolism, and rodent work (preferably mice) is highly sought. Only candidates that have first-author publications in peer-reviewed journals will be considered.  LINK TO POSTING
Self learner and motivated.
Strong organizational skills and stellar work ethic.
Capable of working independently or as a team member.
Previous research experience and a Ph.D. or equivalent.
Proactive problem solver.
Excellent English speaking and writing skills.
Good record of productivity. This will be shown by publications, abstracts, awards, and references.  
Ability to perform basic cell and molecular biology techniques such as Cell Culture, ELISA, Western Blotting, Immunohistochemistry, Fluorescence Microscopy or qRT-PCR.
Willingness and ability to work with mice.
Strong desire to learn about / study cardiovascular research.
Prepare publications, abstracts and oral / poster presentations.
Participate in lab meetings and scientific discussion.
Supplemental Position Information
Please contact Priscila Sato, Ph.D. (pys26@drexel.edu) for additional information  
This position is supported either fully or partially by external funds; therefore, any offer of employment and the continuation of employment are contingent on receipt of those external funds
Drexel University offers an attractive benefits package including tuition remission, a generous retirement package with matching funds (up to 11 percent) and an opportunity to join a talented team of professionals directly helping the University achieve its record growth and quality reputation.
Background investigations are required for all new hires as a condition of employment, after the job offer is made. Employment may not begin until the University accepts the results of the background investigation.
Drexel University is an Equal Opportunity/Affirmative Action employer, welcomes individuals from diverse backgrounds and perspectives, and believes that an inclusive and respectful environment enriches the University community and the educational and employment experience of its members. The University prohibits discrimination against individuals on the basis of race, color, national origin, religion, sex, sexual orientation, disability, age, status as a veteran or special disabled veteran, gender identity or expression, genetic information, pregnancy, childbirth or related medical conditions and any other prohibited characteristic. Please visit our website to view all University Policies and Workplace Postings.  
No  
 
Commensurate with experience  
(5) Full Time  
6326 Pharmacology Control  
NCB, 8th Floor  
I  
03-26-2018  
06-24-2018
www.drexelmedjobs.com/applicants/Central?quickFind=74166  

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Multiple Postdoctoral Opportunities

Date Posted:
6/7/2018

Cincinnati Children's Hospital Medical Center

OH

LINK TO POST

Cincinnati Children’s Hospital Medical Center is a premier pediatric research institution with over 900 diverse and productive faculty members. Here, researchers work collaboratively across specialties and divisions to address some of the biggest challenges we face today in improving child health. A strong network of research support services and facilities, along with institutional commitment to research, push our team of faculty, postdocs and support staff to explore the boundaries of what is possible, leading to significant breakthroughs. We are driven by our mission to improve child health and transform the delivery of care through fully integrated, globally recognized research, education and innovation.

Post-doctoral research fellows at Cincinnati Children’s are valued for their unique interests and strengths, and are supported by our institution’s strong programming for post-docs through the Office of Postdoctoral Affairs and the Office of Academic Affairs and Career Development. Mentoring, support for international students and an emphasis on crafting high-quality grant proposals are only a few of the features that set our program apart. Cincinnati Children’s is a respected part of the broader, and very vibrant, Cincinnati community. With a thriving arts scene, numerous festivals celebrating music and food, a passionate fan following for our college and professional sports teams, and a variety of opportunities for outdoor activities, our region is truly a great place to work and live.


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Postdoc in Noncoding RNA Research

Date Posted:
6/7/2018

The Kornfeld Lab of Noncoding RNA Research, University of Southern Denmark

INT

LINK TO POSTING

We are always happy to receive tailored applications and expressions of interests from postdocs or PhD students with interest in metabolism and noncoding RNAs, epigenomics and methylomics in vivo. In case funding is not available, we are happy to assist you with grant applications and interim financial support to kick-start your research with us!

We are also looking forward to applications from Master (M.Sc.) Students starting in Sommer Semester 2018/19. 

If case you are interested in joining our lab, please send a letter of motivation and 2-3 academic referees to Jan-Wilhelm (Jan-Wilhelm.Kornfeld(AT)sf.mpg.de) or (janwilhelmkornfeld(AT)bmb.sdu.dk).

Noncoding RNAs: Dark matter of the genome

The impact of Noncoding RNAs (ncRNAs) such as microRNAs and, more recently, long ncRNAs (LncRNAs) onto eukaryotic gene regulation has just started to be understood. The Kornfeld lab would like to take part in this 'Noncoding RNA revolution' by identifying novel ncRNAs and elucidating their role in homeostatic circuits regulating energy homeostasis in health and disease. We apply state-of-the art techniques such as next-generation sequencing, the generation of transgenic mouse models and in vivo anti-ncRNA approaches to ultimately better understand the intricate biology of disease-associated ncRNAs. Our ultimatate goal is to define novel sequence-specific anti-ncRNAs therapeutics for anti-obesity intervention.


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Postdoctoral fellowships in computational biology and machine learning

Date Posted:
6/7/2018

The Hoffman Lab at the Princess Margaret Cancer Centre, University of Toronto

INT

LINK TO POSTING

The Hoffman Lab at the Princess Margaret Cancer Centre and the University of Toronto seeks new members for our team. We develop machine learning techniques to better understand chromatin biology. These models and algorithms transform high-dimensional functional genomics data into interpretable patterns and lead to new biological insight. A key focus of the lab is to train a new generation of computational biologists.

Postdoctoral fellowships in computational biology and machine learning

We seek postdoctoral fellows for several projects in computational genomics and machine learning. Selected projects include:

  1. Integrating epigenomic and sequence data to better understand human gene regulation.

  2. Creating models of transcription factor binding that allow us to predict the effects of perturbations.

  3. Developing deep learning techniques to find novel behavior in multiple functional genomics datasets.

We also welcome your project ideas! The project should concern mammalian epigenomics. Cancer relevance preferred.

Required qualifications: Doctorate in computational biology, computer science, electrical engineering, statistics, or physics, obtained within the last five years. Submitted first-author or joint first-author papers in genomics or machine learning research. Experience in scientific programming in a Unix environment.

Not required, but preferred qualifications: Experience with epigenomics and graphical models. First-author papers published in peer-reviewed journals, refereed conference proceedings, or a preprint archive. Experience programming in Python, R, C, and C++.

Benefits: Includes extended medical insurance, dental insurance, maternity benefits (15 weeks), parental benefits (additional 35 weeks), child care program (fee applies), defined-benefit pension plan, and employment insurance. Flexible work hours.

To apply: We will accept applications until the positions are filled. Please submit your CV (as PDF), one representative paper (as PDF), and the URL of a web page containing a code sample written by you (for example, on Bitbucket or GitHub) to join@hoffmanlab.org.

The Princess Margaret Cancer Centre is a teaching hospital and research institute affiliated with the University of Toronto. It has the largest cancer research program in Canada. It is a component of the University Health Network, Canada's largest hospital.

The Hoffman Lab is part of a Centre for Cancer Epigenomics at the Princess Margaret. There are ample opportunities for collaboration and scientific exchange with a large community of genomics, computational biology, and machine learning groups at the University of Toronto and associated institutions, such as The Hospital for Sick Children.

We emphasize the development of research skills for all lab members. Some skills we will help you train in: biological knowledge, machine learning techniques, programming, scientific project management, oral presentations, written communication, scientific publication, grant writing. Michael meets with lab members weekly to discuss research progress and training needs. Lab members receive a written evaluation three times annually.

We particularly encourage candidates who are women or members of underrepresented minorities.


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Postdoc in Computational Biology

Date Posted:
6/7/2018

Netherlands Cancer Institute

INT

LINK TO POSTING

Computational biology position - Genomics of breast cancer and prostate cancer

Project information:
Breast cancer and prostate cancer are the most-commonly diagnosed tumor types, globally. Both tumor types are considered hormone-dependent cancers, and hormonal therapy represents the mainstay therapeutic option for most of these patients. However, resistance to treatment is common, and an urgent clinical need exists to identify novel therapeutic options and to develop new biomarkers for therapy response prediction. Hormone receptors are ligand-dependent transcription factors that associate with enhancer elements to regulate gene expression programs in 3D genomic space.

The project is aimed to identify biomarkers for hormonal treatment response in breast cancer and prostate cancer, and involves multi-dimensional genomic data integration (RNA-seq, ChIP-seq, ATAC-seq, Hi-C, GRO-seq etc). Data from cell lines as well tumor tissue from multiple clinical trials will be used, geared to bring the scientific results swiftly and efficiently to the patient.

The project will employ the complementary expertise and tools from the groups of Wilbert Zwart, specialized in chromatin genomics of breast and prostate cancer and the Computational Cancer Biology group lead by Lodewyk Wessels at the Netherlands Cancer Institute, Amsterdam. The position is will be shared between these groups.

Your profile:

We are seeking highly motivated Postdoc or PhD candidates with a degree in bioinformatics, computer science, mathematics or physics and with a strong cancer biology interest. Preferably applicants should have a strong documented experience in analyzing high-throughput genomics data. Fluency in spoken and written English is a strong requirement.

Your career opportunities and terms of employment:

Postdocs will be employed for a period of 4 years. The gross salary per month will be from € 3.490,- to € 3.917,- according to the FWG – level 55, depending on previous experience. PhD students will be employed for a period of 4 years. The gross salary per month will be from € 2.665,- to € 3.282,- according to the PhD-scales depending on previous experience. The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labour Agreement for Hospitals).

Want more information?
Please contact Dr. Wilbert Zwart (+31 20 512 2101, w.zwart@nki.nl) or Dr. Lodewyk Wessels, (+31 20 512 7987, l.wessels@nki.nl). Also see ccb.nki.nl for further information.

Interested?
Your application letter and resume can be attached before 15 August 2018 to the application form on our website (see link below). After submitting the form, you will receive a confirmation as soon as possible.


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Postdoctoral Research Associate in Machine Learning and Cancer Research

Date Posted:
6/7/2018

Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California

CA

LINK TO POSTING

Find your future at the Lawrence J. Ellison Institute for Transformative Medicine of USC!

We are looking for outstanding individuals from various backgrounds to help us engender transformative changes in the management of cancer and chronic illness. If you are looking to use your expertise alongside world-class researchers to significantly impact human health, well-being, quantity and quality of life, consider joining the team at the Ellison Institute.

Postdoctoral Research Associate

We are seeking a Postdoctoral Scholar Research Associate for the Ruderman Laboratory who has expertise in machine learning and has a strong interest in cancer research. The candidate will collaborate with biological scientists and clinicians to understand their experiments and data to devise predictive machine learning platforms. Expertise in multiple machine learning approaches, including SVMs, DCNNs, and elastic nets is required. The ability to communicate effectively with biologists and clinicians on their own terms is essential. The successful applicant will be capable of working with complex multi-modal data and distilling them into formats appropriate for machine learning. Data sets will include histopathology images, high-dimensional multi-omic data, time series from live cell microscopy, and complex clinical data from electronic medical records. The candidate must be willing to perform low-level data manipulations, including locating/downloading data from public resources, populating databases, and data reformatting. 


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Postdoctoral Scholar in Bioinformatics

Date Posted:
6/7/2018

The Telese Lab, University of California, San Diego

CA

LINK TO POSTING

Postdoctoral Scholar in Bioinformatics

School of Medicine

Medicine

epigenetics, transcriptomics, neuroscience

The Telese Lab in the Department of Medicine at the University of California San Diego seeks an enthusiastic, highly motivated and experienced researcher with a background in bioinformatics and a documented track record in next-generation sequencing data analysis. The Telese lab studies epigenetic mechanisms that regulate gene expression in the brain and their contribution to neurological disorders. We are particularly interested in the role of enhancer elements in the control of chromatin regulatory processes. Our major NIH-funded project focuses on epigenetic and transcriptional changes associated with the abuse of synthetic cannabinoids in adolescence using mice models. Experimental techniques used in the lab include ChIP-seq, RNA-seq, ATAC-seq, GRO-seq, and a variety of cellular and molecular assays. More info to be found here: http://profiles.ucsd.edu/francesca.telese

The successful candidate will contribute to develop an innovative research program involving computational analysis of data and is expected to provide bioinformatics resources to the members of the Lab.

UCSD is committed to build a culturally diverse and inclusive environment. Applications from female and minority candidates are strongly encouraged. 

The position is for two-year contract with possibility of extension. The candidate must be US citizen or permanent resident.

Required skills include:

- PhD in bioinformatics/computational biology or related field

- Proven knowledge of NGS analysis tools

- Capability of working in a collaborative environment

- Excellent communication skills in English 

Two-year contract with possibility of extension

Interested candidates should contact the PI (ftelese@ucsd.edu) and provide a CV and a cover letter

8/10/2018
 
Francesca Telese

ftelese@ucsd.edu
 
(858)246-2607

http://profiles.ucsd.edu/francesca.telese

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Postdoctoral Fellow - Genomic Structures in Leukemia

Date Posted:
6/7/2018

Van Andel Research Institute

MI

LINK TO POSTING

Van Andel Research Institute’s Laboratories of Dr. Gerd Pfeifer and Dr. Xiaotian Zhang in Center for Epigenetics, Van Andel Institue, are seeking to hire a Postdoctoral Fellow to work on a recently awarded EvansMDS Foundation Young Investigator Award. 

The minimum 2-year postdoctoral position, with a possibility of extension pending successful grant applications and performance, is available immediately and intended for a motivated scientist who meets the qualifications and description outlined below. This fellow will investigate three-dimensional (3D) genome structure alterations in the leukemic transformation and the phase separation mechanism of mutant leukemia proteins.

There are two overall goals of this project.

  • The first is to study how the well organized 3D genome structure (TADs and Canyon interactions, Biorixv 2017) and nuclear architechture (nuclear bodies) is disrupted after leukemic transformation. The fellow will use imaging and NGS based tools to access the alteration of 3D genome structure. The fellow will also apply the epigenomic engineering tool to alter the abnormal structure in the transformed cells and dissect the intiating events of such abnormal change.
  • The second is to establish a novel mouse model with the deletion of key Polycomb target region. This fellow will use the CRISPR/Cas9 technology to generate genetic engineering mouse and characterize the phenotype of engineered mouse in limb and hematopoietic system development.

The fellow will primarily be a member of the Xiaotian Zhang laboratory, and directly report to Dr Xiaotian Zhang. As the fellow will be working on joint projects, he/she will also participate in regular group meetings together with both Drs. Xiaotian Zhang and Gerd Pfeifer and interact with both their research groups.

Qualifications:

  • A Ph.D., M.D. or M.D./Ph.D. in molecular biology, biochemistry, and/or molecular genetics with preferred expertise in hematopoiesis.
  • Experience of working with epigenomic profiling method like ChIP-seq, WGBS and RNA-seq.
  • Previous experience with protein expression and mouse models.
  • A record of peer-reviewed publications is highly desirable.

Scientific Support for the Fellow

  • One supporting technician
  • Well trained lab technician team for support in NGS library preparation and imaging analysis.
  • State-of-Art core facilities on genomics, flow-cytometry, Vivarium and microscopy

Description of a Successful Candidate:

  • A self-motivated and driven individual who is able to exhibit exceptional research productivity and take responsibility for management of the project.
  • A detail-oriented researcher that thinks critically to effectively design experiments and solve complex research problems.
  • A strong ability to take initiative and work independently, as well as in a team environment.
  • A collaborative, hands-on researcher who proactively shares knowledge and expertise with lab members.
  • Excellent written and oral communication skills.

Van Andel Research Institute (VARI) provides postdoctoral training opportunities to scientists beginning their research careers. The fellowships are to help promising scientists advance their knowledge and research experience and at the same time support the research endeavors of VARI under the mentorship of a VARI Faculty member.

While this project is currently funded, an integral part of postdoctoral training is the process of preparing a research proposal and writing a fellowship application. All VARI Postdoctoral Fellows are encouraged to apply for external funding as soon as it is practical and reasonable after hire. Receiving a fellowship award provides recognition for both the fellow and VARI!

If you possess these attributes and desire to help us drive science from the bench to the clinic; while benefiting from a highly generous compensation package; we would welcome speaking with you and encourage you to apply today by visiting.

The Center for Epigenetics is a growing research environment with focus on epigenetic machenisms of human disease. The fellows will benefit from a training environment with weekly joint journal clubs, regular center joint meetings, regular extramural seminar speakers and chance for major scientific meetings in U.S..

Application Process:

Qualified applicants should provide the following document to to Xiaotian Zhang,  xiaotian.zhang@vai.org.

  • A very brief two paragraph, one-page limit cover letter outlining research experience and future research interests/plans.
  • A curriculum vitae.

VAI is actively striving to diversify its workforce and strongly encourages qualified individuals from underrepresented groups to apply. Van Andel Institute is an EEO and Affirmative Action Employer.

This position will be open until filled. If you have any difficulty uploading your application or any questions, please email Eric Miller at eric.miller@vai.org


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Postdoctoral Researcher, Cancer

Date Posted:
6/4/2018

University of Pennsylvania - Perelman School of Medicine

PA

JOB DESCRIPTION
The Drapkin laboratory at the University of Pennsylvania (Penn) is seeking to expand their work on early tumor development and progression, cancer genomics and epigenetics, and lineage dependencies. The goals of the lab are to translate important discoveries into clinically useful diagnostic and therapeutic tools. Several postdoctoral positions are immediately available for outstanding candidates.

ABOUT THE EMPLOYER
Dr. Drapkin is the Director of the Penn Ovarian Cancer Research Center (OCRC). Established in 2007, the OCRC serves as a catalyst to promote comprehensive and interdisciplinary research on ovarian cancer. Penn is the oldest and one of the finest medical schools in the United States. It is rich in tradition and heritage and at the same time consistently at the forefront of new developments and innovations in medical education and research. Since its founding in 1765 the School has been a strong presence in the community and prides itself on educating the leaders of tomorrow in patient care, biomedical research, and medical education. Penn offers competitive salaries and outstanding benefits.

DESIRED SKILLS AND EXPERIENCE
We seek candidates with a PhD or MD-PhD with a strong background in biochemistry, molecular biology, and basic computational biology. Preference for candidates with experience in developing and characterizing genetically engineered mouse models will be given. The successful candidate must be well organized and capable of working independently as well as collaboratively. The postdoc should be fluent in English, possess excellent writing skills, be able to independently analyze experimental results, and think creatively. A record of prior publications is required. We are only interested in highly motivated and talented scientists with a strong work ethic who are committed to solving important questions in cancer biology and are willing to stay at least 4-5 years. The successful candidate will have completed their graduate degree in or after 2016, and be a US citizens or permanent resident.

Visit the Drapkin lab website for more details: https://www.med.upenn.edu/drapkinlab/

Please submit a motivation letter along with three reference letters and your CV to Dr. Drapkin at drapkinlabpostdoc@gmail.com


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Postdoctoral scientist in Electrical Engineering/Synthetic Biology/Chemistry

Date Posted:
6/7/2018

Shih Microfluidics Laboratory, Concordia University

INT

The mission of the Shih Microfluidics Laboratory is to develop miniaturization tools to solve challenges related to health, energy, and synthetic biology. Our approach to solving these challenges are to use miniaturization technologies, such as microfluidics, and automation approaches and techniques. Students in my lab are inter-disciplinary - combining principles in electrical engineering, molecular biology, and chemistry. Current projects in my lab include designing microfluidics automation systems for gene-editing, developing new microsystem tools for discovering new enzymes related to biofuel production, and integrating miniaturization to expedite processes related to synthetic biology. We strongly encourage ‘hybrid’ students that will bring new scientific creativity among our students and we are always open to new projects and ideas that are related to these areas. We are very collaborative with other labs from different disciplines and welcome new students and postdocs from diverse backgrounds such as biology, engineering, chemistry, and computer engineering/science. Below are current openings for talented and strongly motivated students and postdocs.

• Postdoctoral scientist in Electrical Engineering/Synthetic Biology/Chemistry o The postdoctoral scientist can either have a background in 1) Electrical Engineering, 2) Biology, or 3) Chemistry. This postdoc will have the opportunity to work on a number of different synthetic biology based microfluidic projects.

To apply, please email Steve Shih your recent CV with cover letter, the job title you are applying for in the subject line, and contact information of at least two references. Postdocs please send three references. Contact: Steve Shih, Ph.D Assistant Professor Department of Electrical Engineering Center for Applied Synthetic Biology Concordia University Montreal, QC, Canada Email: steve.shih@concordia.ca

LINK TO POSTING


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Postdoctoral Researcher, Memory Epigenetics and addiction

Date Posted:
6/4/2018

Temple University

PA

A Postdoctoral Researcher position is available in the Memory Epigenetics and Addiction Laboratory at Temple University. The lab focuses on the epigenetics of drug addiction using pre-clinical rodent models. We are seeking an experienced molecular biologist to assist with studies of the transcriptome and epigenome following exposure to drugs of abuse.  

The successful candidate will be expected to participate in multiple projects studying changes to epigenetic processes in the brain and germline following chronic opioid exposure. The candidate will have a Ph.D. in neuroscience, biology or related fields, a strong background in statistics, and extensive experience with molecular biology. The candidate must have strong communication and interpersonal skills, and be capable of working with large collaborative teams. 

Technical expertise in standard basic molecular and cellular techniques, including chromatin immunoprecipitation (ChIP), quantitative PCR (qPCR), and Western blotting is required for this position. Experience generating and analyzing large sequencing data sets is preferred. Candidates must be enthusiastic, self-motivated, dedicated to science and problem-solving. Responsibilities will include leading projects, data processing, drafting manuscript and assisting with grant applications for the lab. The candidate must be willing to assist our team in its collective research goals, be detail oriented and possess strong organizational skills. The candidate will be expected to manage and work on multiple projects. Please submit a cover letter, CV and the names of three references.

Apply here! 


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Postdoc, Cell and cancer biology

Date Posted:
6/4/2018

University Medical Center Utrecht

INT

For a joint FET-H2020 Research and Innovation project with the De Rooij Laboratory (Department of Molecular Cancer Research) we are looking for a Postdoc (PhD). The project encompasses studies into the cell/ECM and cell/cell contact interphase and how these interactions control mammary gland homeostasis and breast cancer progression. Background should be Molecular Biology or Biochemistry. Candidates have a strong interest in cell biology and clinically relevant translational research focused on tumor progression.
?
An absolute must is broad experience in cell biology (ranging from viral reconstitution experiments and functional cellular assays to high-end confocal microscopy in 3D cultured cell lines and primary tumor material). Knowledge of cell-cell and cell-matrix adhesion biology is strongly preferred. If you have a licence for working with animals (mice), it would be a BIG plus.


This is a full time temporary positions for 3 years.

For more information, click here


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NCI Cancer Prevention Fellowship Program (CPFP)

Date Posted:
6/4/2018

National Cancer Institute

MD

Preventing cancer is one of the most important scientific and public health aims for the 21st Century. To achieve that goal, the Nation needs leaders: scientists and health professionals trained in the principles and practice of cancer prevention and control.

Founded in 1987, the NCI Cancer Prevention Fellowship Program (CPFP) provides its fellows an opportunity to develop an independent research program in cancer prevention. The centerpiece of the program is mentored, multidisciplinary research. With input from senior scientists and program staff, each fellow develops original scientific projects and reports findings at meetings and in leading journals.

The program provides:

  • Competitive stipends, relocation expenses, health insurance benefits, and travel allowances
  • Support for up to four years
  • Opportunity to earn your MPH, sponsored by NCI
  • Research opportunities with experienced NCI mentors
  • A cohort of fellows spanning STEM and other fields

Our program is regularly evaluated and growing. Our?alumni?across the country are taking the lead at cancer centers, universities, government agencies, research firms, and policy organizations, and in clinical practice. Many former fellows now act as mentors, assisting those who are following in their footsteps.

Our Goal

We are committed to providing a comprehensive postdoctoral program that is flexible enough to permit individual creativity and resourceful enough to provide opportunities for meaningful discoveries. Unlike some postdoctoral programs, our fellows have the opportunity to select their own?preceptors, and develop and lead research activities based on their own interests.

World Class Training Opportunities

Research opportunities for Cancer Prevention Fellows reflect the broad origins and applications of many biomedical sciences relevant to public health and clinical medicine. The program offers opportunities for basic science laboratory studies, epidemiologic studies, intervention trials, health services research, and studies of the biological and social aspects of health behavior. Further, an initiative of NCI and the FDA allows fellows to apply research in drugs, biologics, medical devices, and other areas to the field of cancer prevention.

We encourage you to learn more about the unique features of the CPFP through testimonials?from current fellows and alumni by?viewing this short video.

On behalf of all of us who are committed to eliminating death and suffering from cancer?patients, physicians and nurses, researchers, other scientists, and the general public?we urge you to join us in this endeavor. Please read the eligibility requirements and?submit your application. We look forward to hearing from you.


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Post-doctoral level Data Scientist position in machine learning and computational biology

Date Posted:
6/7/2018

Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai

NY

 

LINK TO POSTING

Description:

A post-doctoral level NIH-funded data scientist position is available in the group of Prof. Gaurav Pandey (http://www.mountsinai.org/profiles/gaurav-pandey) at the Icahn School of Medicine at Mount Sinai in New York City. The target project for this position is the development of novel machine learning algorithms to extract enhanced predictions and actionable knowledge from crowdsourcing operations. These algorithms will be applied to DREAM challenges (http://dreamchallenges.org) with the goal of improving the community’s ability to address difficult biomedical problems. Plans have also been made to evaluate and translate the findings from this work in clinical settings. This work will be conducted in close collaboration with IBM Research and Sage Bionetworks.

Our group focuses broadly on developing and applying machine learning methods to build network and predictive models of biological processes from large biomedical data sets. It is a part of the recently formed Icahn Institute of Genomics and Multiscale Biology (http://multiscale.mssm.edu) at the Icahn School of Medicine at Mt Sinai. The Institute aims to revolutionize the field of genomic medicine by bringing to the table skills from very unorthodox disciplines (for biology), such as computer science, statistics, physics and high-performance computing. The faculty members of the institute, experts in all these areas, analyze large biomedical data sets to build accurate models of biological processes and complex diseases, such as cancer, type-2 diabetes and Alzheimer’s disease. Being positioned within a prominent medical center such as Mount Sinai makes it feasible to bring the predictions and therapeutic discoveries from these models to the patients’ bedside, thus placing the institute in a very unique position.

The selected candidate will be able to contribute to the ongoing projects in the group and the Institute, as well as define his/her own projects.


Qualifications:

Candidates should have a recent PhD degree in a computer science, computational biology, bioinformatics, systems biology or related field. Strong computational and machine learning expertise are required. Familiarity with large-scale data analysis and biology are a plus. The candidate should have discipline and high motivation to pursue independent research in computational biology. Applicants are also expected to have a solid background in programming and computational techniques.


Start date:

As soon as possible


How to Apply:

To apply, send a CV, a research statement and three reference letters to gaurav.pandey@mssm.edu


Contact:

Gaurav Pandey

 

Icahn School of Medicine at Mount Sinai

Genetics and Genomic Sciences

United States NY New York

http://research.mssm.edu/gpandey/


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Postdoctoral Associate in Behavioral Neuropharmacology

Date Posted:
6/7/2018

School of Medicine, Virginia Commonwealth University

VA

LINK TO POSTING

A postdoctoral position funded by an NIH training grant is available immediately for a behavioral neuropharmacologist at the Virginia Commonwealth University (VCU) School of Medicine in the laboratory of Dr. M. Imad Damaj.  The candidate will study mechanisms underlying nicotine dependence and chronic pain.

The candidate will have the opportunity to integrate molecular, biochemical, genetic and anatomical approaches in ongoing multidisciplinary projects to study mechanisms of nicotine dependence, pain and neuropathy. The candidate will join a Lab that utilizes interdisciplinary molecular, pharmacological, anatomical, and behavioral approaches in rodent models, in an environment that provides multidisciplinary training in neuropharmacology.

Interested individuals are encouraged to forward a curriculum vitae, a list of three references, and a statement of research interests and career goals to M. Imad Damaj, Ph.D., Department of Pharmacology & Toxicology, Box 980613, Virginia Commonwealth University, Richmond VA 23298, or via email to: m.damaj@vcuhealth.org.

The candidate must be a United States citizen or permanent resident.  A Ph.D. and/or M.D. and experience in neuropharmacology or basic neuroscience are essential.Experience in rodent operant behavior and surgery skills are preferred. The candidate will be provided with significant training in those disciplines with which they are less familiar, as well as mentoring to facilitate the transition to an independent research career.

 
NOTES: Additional Salary Information: NIH stipend -Based on experience
Internal Number: 022

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Postdoctoral Fellow(s) in Metabolite Signaling

Date Posted:
6/7/2018

Department of Molecular Biosciences, University of Texas at Austin

TX

Postdoctoral Fellow positions:

Postdoctoral positions are available in the Cambronne Lab for studies in metabolite signaling using fluorescent biosensors. The goals of these projects include elucidating signaling roles for NAD+ in aging cells and tissues, as well as expanding our repertoire of fluorescent biosensors to other metabolites.

The metabolism of our cells impacts our health and how genes are read, even in ways that are passed on to our children. In additional to redox biology, free intermediary metabolites such as NAD+, can serve as signaling molecules to communicate between compartments and regulate gene expression to impact cellular health and disease. Our members led the development of a DNA-based fluorescent biosensor to obtain the first direct subcellular measurements of free NAD+. We continue to study how the levels of NAD+ and other metabolites are locally regulated and to determine their critical thresholds for health.

We are a collaborative team of creative researchers, who strive towards discoveries through innovation. This group is led by Assistant Professor Lulu Cambronne, and we are in the Department of Molecular Biosciences at the University of Texas at Austin. Our research environment supports individual initiative and critical thinking, as well the training of future generations of scientists. We uphold a high standard in scientific rigor, and tackle challenging problems in cell biology, molecular biology, biochemistry and physiology to glean insight into disease onset and progression.

Interested candidates within 2 years of receiving their PhD are encouraged to apply. Prior expertise in molecular and cellular biology is required.

To apply, please email CV and contact information for 3 references to lulu@austin.utexas.edu


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Postdoctoral position in Computational Neuro-Epigenomics

Date Posted:
6/4/2018

University of California, San Diego

CA

Postdoctoral position in Computational Neuro-Epigenomics

 The UCSD Computational Neural Data and Dynamics Lab, led by Prof. Eran Mukamel, is seeking applications for a funded postdoctoral research position as part of our group�s studies of epigenomic regulation in brain cells. Our lab in the University of California, San Diego (UCSD) Cognitive Science department uses tools from bioinformatics and machine learning to analyze a variety of neural epigenetic processes. We have identified unique forms of DNA methylation in neurons and glial cells, and we are working to understand the distribution, development and potential function of these epigenomic marks. Our theoretical and computational research group has close ties with experimental neurobiology and genomics labs in San Diego. More information about the lab is at http://brainome.ucsd.edu.

Applicants should hold a Ph.D. (or expect to receive one shortly) and have a strong background in computational biology (e.g. computational neuroscience, bioinformatics), or physical science or engineering (e.g. math, physics, computer science, bioengineering) as well as a strong interest in fundamental genomic processes underlying neural development and cognition. Previous experience with genomic or epigenomic data analysis is an advantage, but not necessary.

To apply, please send the following to Prof. Mukamel (emukamel@ucsd.edu):

    • A cover letter describing your background, research interests and how they fit with our lab
    • Curriculum vitae
    • Contact information for 2-3 references
    • If available, a sample of the applicant�s work, e.g. a manuscript, thesis, or other work product
    Salary will be commensurate with NIH rates. For inquiries or more information, please contact Eran Mukamel at the address above.

 


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Postdoc: Cincinnati Children's Center for Autoimmune Genomics

Date Posted:
6/4/2018

Cincinnati Children's Center

OH

Cincinnati Children's Center for Autoimmune Genomics   

 Postdoctoral Position Currently Available Center for Autoimmune Genomics and Etiology (CAGE) Genomic technologies (ChIP-seq, EMSA, DAPA, ATAC-seq, DNA methylation, and others) are being applied in Dr. Harley’s laboratory to reconcile genetic associations with the environmental causes of idiopathic autoimmune disorders with the goal to elucidate mechanisms initiating these pathological processes. The candidate would join a team that has uncovered unexpected and powerful associations of transcription factors with genetic loci, with the goal to establish the genetic mechanisms. The team in place has the strategic, informatic, clinical, and technical expertise to provide strong support for the candidate in addition to the other resources and personnel of the Center for Autoimmune Genomics and Etiology (CAGE). The disorders with direct relevance to this position include lupus, rheumatoid arthritis, multiple sclerosis, type 1 diabetes, inflammatory bowel disease, chronic lymphocytic leukemia, Hodgkin’s disease, and many others. Website: https://www.cincinnatichildrens.org/research/divisions/a/genomics-etiology/team?… 

Qualifications: The ideal candidate will have a PhD with training in genetic epidemiology with a familiarity with genomic molecular laboratory methods (e.g., ChIP-seq, CRISPR-Cas9, EMSA, DAPA, etc.). Deep familiarity with genome wide association studies for any complex genetic disease phenotype would be important. Preference will be given to applicants with experience with informatic expertise, including genome wide association studies, the analysis of next generation sequence data, large genotyping datasets, and data mining, in general, along with demonstrated scholarly productivity by discovery and publication.

Please submit your application to Dr. Harley with the following information: A cover letter, a statement of interest, and a CV with contact details for 3 referees. Contact: John Harley, MD, PhD Email Address: John.Harley@cchmc.org

Cincinnati Children’s Research Foundation Cincinnati Children’s Hospital Medical Center (CCHMC) is a premier pediatric research institution with over 900 diverse and productive faculty members. Here, researchers work collaboratively across specialties and divisions to address some of the biggest challenges we face today in improving child health. A strong network of research support services and facilities, along with institutional commitment to research, push our team of faculty, postdocs and support staff to explore the boundaries of what is possible, leading to significant breakthroughs. We are driven by our mission to improve child health and transform the delivery of care through fully integrated, globally recognized research, education and innovation. Post-doctoral research fellows at Cincinnati Children’s are valued for their unique interests and strengths, and are supported by our institution’s strong programming for post-docs through the Office of Postdoctoral Affairs and the Office of Academic Affairs and Career Development. Mentoring, support for international students and an emphasis on crafting high-quality grant proposals are only a few of the features that set our program apart. Cincinnati Children’s is a respected part of the broader, and very vibrant, Cincinnati community. With a thriving arts scene, numerous festivals celebrating music and food, a passionate fan following for our college and professional sports teams, and a variety of opportunities for outdoor activities, our region is truly a great place to work and live.

Postdoctoral Affairs Office: http://www.cincinnatichildrens.org/education/research/postdoctoral/default/?… Questions? Contact CCHMC Postdoc recruiter: Uma Sivaprasad, Ph.D. – research@cchmc.org To apply online go to: http://jobs.cincinnatichildrens.org/us/en-us/search-jobs/XsjgP?… and search for job (requisition) number 99288. Cincinnati Children’s Hospital Medical Center is an Affirmative Action/Equal Opportunity Institution 

 


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Postdoctoral position in pathogenesis of Escherichia coli

Date Posted:
6/4/2018

Penn State

PA

Postdoctoral position in pathogenesis of Escherichia coli O157:H7

The Dudley lab (http://foodscience.psu.edu/directory/egd100) at The Pennsylvania State University has an NIH-funded postdoctoral position available to investigate the role of nonpathogenic E. coli in modulating Shiga toxin production by E. coli O157:H7. Previous and unpublished studies have identified several mechanisms driving this process. By leveraging the >80,000 isolates cataloged in Penn State’s E. coli Reference Center

(http://foodscience.psu.edu/research/centers/ecoli), the project goals are to mechanistically define known processes and to identify new ones. The Dudley lab is located in the Department of Food Science and is one of several labs there applying tools of molecular biology and genomics in food safety research. Penn State has excellent core facilities including genomics, proteomics and mass spectrometry, and metabolomics, and the Huck Institutes of the Life Sciences maintains a campus-wide culture of excellence in infectious disease research.

The candidate should have a Ph.D with a strong background in bacterial genetics and/or biochemistry, and experience with microbial infectious disease agents. Leadership skills and a willingness to leverage expertise in collaborative projects with graduate students and postdoctoral fellows are expected.

Penn State is located in central Pennsylvania within the Nittany Valley. The region enjoys the advantages of a mid-sized college town, and has outdoor activities including hiking, mountain and road biking, and world-class fly fishing within minutes of campus.

Interested candidates should submit a CV, letter summarizing research interests and career goals, and contact information for three references to dudley@psu.edu.


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Postdoc-Computational Biologist

Date Posted:
6/4/2018

Memorial Sloan Kettering Cancer Center (MSKCC)

NY

An open position for a postdoc or scientist in computational biology with experience in transcriptomics is available in the laboratory of Christine Mayr at Memorial Sloan Kettering Center in New York.

The lab studies the evolution and functions of 3′UTRs. 3′UTRs are best known to regulate protein abundance. However, we recently discovered that 3′UTRs can also regulate protein functions by mediating protein-protein interactions (Berkovits & Mayr, Nature 2015; Mayr, Annu rev genet 2017). This finding indicates that not all the information about protein function and protein localization is contained within a protein. Instead, the information is encoded within the non-coding parts of mRNAs and is transferred onto the proteins while being synthesized. We propose that 3′UTRs contribute to functional complexity of higher organisms. To study new 3′UTR functions Dr. Mayr was awarded the NIH Director’s Pioneer Award.

For more information, please visit our web page: https://www.mskcc.org/research-areas/labs/christine-mayr

We are seeking a talented and highly motivated individual to join the lab.

We are currently mostly interested in transcriptomic analysis of 3′UTRs in yeast and mammalian cells and the contribution of 3′UTRs to protein functions. However, we would also like to study evolutionary questions and make use of long read sequencing data sets. The successful candidate will process, analyze, and interpret RNA-seq, 3′-seq, ribosome profiling, and proteomic data sets. There will be a lot of room for innovation.

Responsibilities
- Lead the development of new methods and algorithms to bring together different transcriptomic data sets and apply statistical methods to the analysis.
- Work closely with molecular biologists in the planning of experiments.
- Provide bioinformatics resources for day-to-day use by members of the laboratory.

Application Requirements 
We are seeking a highly motivated candidate with a Ph.D. in Bioinformatics, Computational Biology, Computer Science or related fields. The ideal candidate will have a record of creativity, productivity and scientific rigor with a strong publication record in peer-reviewed scientific journals. The candidate must demonstrate initiative and the ability to work independently in a multidisciplinary, fast-paced and results-oriented environment. Furthermore, excellent organizational and communication skills are required as well as experience and understanding of algorithms, data structures and programming for analysis of biological data. He/she should have a background in transcriptomics. Understanding of molecular biology and biochemistry is a plus.

What we provide
Salary is competitive and commensurate with experience. MSKCC offers dedicated housing for postdoctoral fellows and a large number of benefits. This is a 1-year appointment with possibility of renewal for up to 5 years based upon satisfactory job performance, continuing availability of funds, and on-going operational needs.

The Mayr lab is located in the Mortimer B. Zuckerman Research Center of the Sloan Kettering Institute of MSKCCMSKCC combines laboratories with a focus on basic as well as cancer research. MSKCC is located in a vibrant hub of world-renowned biomedical research institutions in New York’s Upper East Side, adjacent to Rockefeller University and the Weill Cornell Medical College. The vast resources within MSKCC and the surrounding institutions will help to facilitate the success of the applicant’s projects and enable to establish collaborations with other laboratories.

How to apply
Applicants should submit their CV, a letter outlining interest and motivations and names and contact information of three references to mayrc@mskcc.org, with “Computational Biologist” in the subject line.


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Postdoctoral Researcher in RNA detection and analysis

Date Posted:
6/7/2018

The RNA Institute, University at Albany

NY

LINK TO POST

Research focus: Developing new tools for RNA detection and analysis using single- moleculre and DNA nanotechnology approaches

We are seeking a highly motivated and independent individual interested in working with advanced single-molecule techniques and DNA nanotechnology to advance RNA detection and analysis. Specific projects involve further development and application of the Centrifuge Force Microscope (CFM) to identify and analyze individual RNA molecules, and continued development of our “DNA nanoswitch” biosensor for RNA applications.

The ideal candidate will have a keen interest in technology development, along with engineering experience and wet lab experience with molecular biology techniques.

Minimum Qualifications:

• Ph.D. in Biomedical Engineering, Biophysics, Biochemistry or related field from a college or university accredited by USDOE or an internationally recognized accrediting organization

Preferred Qualifications: • Background in single-molecule biophysics (optical tweezers, AFM, etc.) • Hands-on engineering and prototyping experience • Experience/familiarity with DNA nanotechnology/DNA origami • Expertise in optics, image analysis, or programming

Contact khalvorsen@albany.edu with your CV if you are interested.


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Postdoctoral Training in Vascular Physiology

Date Posted:
6/4/2018

Augusta University, Georgia Prevention Institute

GA

Postdoctoral Training in Vascular Physiology
August University, Georgia Prevention Institute 
 
An NIH funded postdoctoral research position is available in the Laboratory of Integrative Vascular and Exercise Physiology (www.LIVEP.net) at The Georgia Prevention Institute (GPI) of Augusta University. The GPI is a clinical research facility that currently has 10 faculty members with a wide range of interdisciplinary clinical and translational research interests including integrative physiology of cardiovascular, pulmonary, metabolic, and renal disease, as well as behavioral, genetic and epidemiological foci. Members of the Institute receive extramural support from a variety of sources, such as the National Institutes of Health and the American Heart Association.
 
The Harris lab has a history of funded research investigating the mechanisms of vascular endothelial dysfunction
and impaired blood flow regulation in different patient populations. Emphasis of the current position will be placed on a recently funded NIH R01 related to vascular dysfunction in patients with type 1 diabetes. Trainees will have access to a variety of state-of-the-art human physiological techniques including ultrasound, NIRS , tonometry, finapress NOVA, laser Doppler imaging and flowmetry, iontophoresis, microdialysis, and pulmonary function.
 
Although outstanding candidates in all areas of physiology will be considered, special consideration will be given to individuals who have 1) experience working with clinical populations, 2) experience with molecular techniques, and 3) a background in cardiovascular, metabolic, or renal physiology. Experience using Doppler ultrasound and assessment of muscle sympathetic nervous system activity (MSNA) using microneurography in humans is preferred, but not necessary. Candidates should 1) have experience working in clinical research, 2) have good communication skills (written/spoken English), 3) are eager to learn, and 4) be eligible for NIH post-doctoral fellowship funding. Salary is determined by NIH postdoctoral fellowship stipend levels.
 
Please send curriculum vitae, a statement of research interests and the names of three references to: Ryan A Harris, PhD., Director, Laboratory of integrative vascular and exercise physiology of Georgia Regents University at ryharris@augusta.edu
 
 

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Postdoc in Systems Immunology, Immune Engineering

Date Posted:
6/4/2018

University of Maryland-Baltimore County

MD

Postdoc in Systems Immunology, Immune Engineering

University of Maryland-Baltimore County

The Szeto Lab (http://gregoryszeto.com/) is hiring a postdoc focusing on systems immunology and immune engineering. Our multidisciplinary team works at the interface of immunology, bioengineering, and systems biology by 1) defining regulatory and organizational principles of immunity, 2) engineering new therapies for vaccines, cancer, and autoimmunity, and 3) developing new platforms and analytical models to predict immune system function during immunotherapies. Project areas include studies in population, sparse cell, and single cell immunology that utilize multiple -omics data types (transcriptomics, metabolomics, epigenomics, dynamics). Problems being addressed are diverse including immunometabolism, mathematical models of immune function, and developing new technologies to analyze and predict cancer immunotherapy.

The ideal candidate has prior expertise in systems biology, particularly -omics data analysis, and wants to significantly broaden their wet lab expertise while continuing to develop algorithms and/or analytical pipelines. The candidate is expected to lead 1 existing project and develop a new independently developed project area. This helps broaden our internal expertise and gives the candidate opportunity to write external fellowship applications. Independently developed research ideas can be negotiated for continued non-competitive investigation by the postdoc in future positions.

A renewable annual contract will be in place with a minimum 2 year commitment. Training opportunities include mentored grant writing via fellowships, extensive written and oral presentations, tech transfer and development of intellectual property, work on preclinical or clinical trials, collaborative and mentoring network with academics, clinicians, industry, and federal agencies as desired per the candidate’s career goals. A mentorship committee of faculty members will be formed to support the candidate’s career development, and regular structured feedback will be given along with a plan of action to achieve desired milestones and future career steps. Applications will be evaluated continuously until the position is filled. Start date as early as Summer 2018.

Minimum qualifications-

  • PhD in engineering (Chemical, biological, computer), immunology, biology, biomedical sciences, or other relevant discipline.

  • Experience with at least one of the following data types - transcriptomics, metabolomics, epigenomics, longitudinal imaging/highly multiplexed imaging, other high dimensional data (define)

  • Must be willing to work with human and mouse samples

Preferred qualifications-

  • Expertise in standard molecular biology and biochemistry techniques, mammalian cell culture (primary cells or cell lines)

  • Proficiency in two or more of the following - flow cytometry/Cytof, RNAseq, microfluidics, nanotechnology, drug delivery (nano/microparticles), genetic engineering (crispr, viral vectors), biomaterial and/or polymer science, computational biology (including R, Matlab or python

  • Demonstrated team leadership and mentorship (or interest in developing these skills) with PhD and undergraduate students

To apply, please send the following to gszeto at umbc dot edu

  1. Cover letter detailing personal interest and perceived fit for the lab, goals for postdoc period,long term career goals, strengths, and high priority areas of improvement

  2. CV

  3. 3-5 professional references

  4. 1-3 first author publications (preprints and peer reviewed accepted) with 2-3 sentences each

    summarizing the study’s significance in field and relevance to future directions in our lab. You may cite non-first author papers, but clearly describe contributions.


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Posdoc in Experimental Geochemistry

Date Posted:
6/7/2018

Colorado School of Mines

CO

Research positions available in experimental geochemistry and reactive transport modeling at Colorado School of Mines

We seek individuals for two research position available in experimental geochemistry and reactive transport modeling of mineral dissolution in heterogeneous porous media. The project objectives are to quantify the effects of heterogeneity in pore structure on spatial distribution of pore-scale dissolution rates and relationships to effective reaction rates. 

We seek exceptional individuals with backgrounds in hydrology, geochemistry, materials engineering or characterization or a related discipline. Experience integrating experimental data with reactive transport simulation in heterogeneous systems is desirable. 

To apply please send a curriculum vitae, a one page narrative summary of research and names and contact information of two references to Professor Alexis Navarre-Sitchler (asithcle@mines.edu). Review of applications will begin immediately and continue untill the positions are filled.


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Innate Immunity to Meningoccal Infections

Date Posted:
6/4/2018

Pasteur Institute

INT

Postdoctoral position
Innate immunity to meningococcal infections
Institut Pasteur Paris
Paris, France
 
Pathogenesis of vascular infections unit
Headed by Guillaume Duménil
 
Topic. Infectious diseases leading to colonization of the blood by the infectious agent are a major burden to society and lead to a wide array of devastating clinical manifestations including septic shock, hemorrhagic syndromes and infection of the brain (meningitis). The main goal of the proposed project is to decipher the pathophysiological processes underlying these infections focusing on the innate immune response to intravascular colonization by the bacterium Neisseria meningitidis. A xenograft-based humanized mouse model of infection by this bacterium will enable in vivo characterization of the innate immune response
(Bonazzi et al. and Melican et al.). The experimental approach will be based in particular on dedicated in-house spinning disk confocal microscopy-based intravital imaging allowing fast, high-resolution multicolor imaging.
 
Bonazzi D, Lo Schiavo V, Machata S, Djafer-Cherif I, Nivoit P, Manriquez V, Tanimoto H, Husson J, Henry N, Chaté H, Voituriez R, Duménil G (2018) Intermittent pili-mediated forces fluidize Neisseria meningitidis aggregates promoting vascular colonization. Cell, In Press.
 
Melican K, Michea Veloso P, Martin T, Bruneval P, Dumenil G (2013) Adhesion of Neisseria meningitidis to dermal vessels leads to local vascular damage and purpura in a humanized mouse model. PLoS Pathog 9: e1003139.
 
Context. This research will take place in a young and dynamic group with a strong background in microbiology, cell biology, immunology, animal models of infection and intravital imaging (https://research.pasteur.fr/fr/team/pathogenesis-of vascular-infections/). Core facilities of the Institut Pasteur campus are also available in support for the project.
 
Skills. We are looking for a highly motivated young investigator trained in the field of immunology and preferably with experience in animal experimentation, surgery, intravital imaging, histology and cytometry with the will to decipher pathophysiological mechanisms of infectious diseases.
 
This full-time position is for 2-3 years (subject to satisfactory review at 12 month)
 
Applications should be directed to Dr Guillaume Dumenil at guillaume.dumenil@pasteur.fr
 
To apply please submit by email a letter of interest, curriculum vitae and names for two references.

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Postdoctoral Associate in Genomic Solutions

Date Posted:
6/7/2018

The Jackson Laboratory

ME

The Jackson Laboratory

www.jax.org/postdoc

As a Postdoctoral Associate at The Jackson Laboratory (JAX), you will conduct cutting-edge research at our expanding academic research campuses in Bar Harbor, Maine and Farmington, Conn., helping to develop precise genomic solutions for disease and improve human health.  Working in our basic science laboratories with our independent faculty principle investigators, JAX Postdoctoral Associates employ multidisciplinary approaches to help us better understand, diagnose, and treat human disease with the ultimate goal of finding cures for cancerheart diseasediabetesAlzheimer's and other ailments.  JAX has developed a postdoc-centric integrative training program to facilitate career success for our postdoctoral trainees inside and outside of academia in both research and non-research careers including programs like our signature The Whole Scientist course.  Postdoctoral Associates interested in pursuing an independent research program can apply for the JAX Scholar Program in their first year of training.  To learn more about our academic postdoctoral positions, visit jax.org/postdoc.

JAX research and postdoc training links:

www.jax.org/postdoc

www.jax.org/scholar

www.jax.org/thewholescientist

www.jax.org/faculty

 

Academic and Translational Research Areas at JAX Include:  

Aging

Bioinformatics

Cancer

Computational Biology

Development

Epigenetics

Genomics

Immunology

Infectious Disease

Metabolism

Microbiome

Neurobiology

Reproduction

Systems Genetics


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Stem Cell Post-Doctoral Research Position

Date Posted:
6/4/2018

Washington University

MO

 
Post-Doctoral Research Position 
 
Post-doctoral research positions are available in the laboratory of Dr. Grant Challen at Washington University in St. Louis studying stem cells, epigenetics and leukemia. For more details see our recent publications in Cell Stem Cell, Blood, Leukemia, Nature
Communications, Cell Reports and more...
 
 

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Postdoctoral Research Associate in Gene Regulation

Date Posted:
6/7/2018

School of Medicine, University of North Carolina

NC

LINK TO POSTING

We are looking for a highly motivated and creative postdoctoral fellow to study mechanisms of gene regulation during human development using state-of-the-art molecular, genetic (CRISPR/Cas9), and genomic (Hi-C, ChIP-seq, ATAC-seq and RNA-seq) approaches. We are particularly interested in understanding the mechanisms through which enhancers and three-dimensional chromatin structure alter transcriptional output during cellular differentiation. The successful applicant will use targeted and genome-wide approaches to study transcriptional control during immune cell development both in normal conditions and within the context of the tumor microenvironment. Our research is highly interdisciplinary and involves cutting edge DNA sequencing technology, bioinformatic analysis, and genome editing. We encourage applicants with relevant experience—either experimental or computational—and those looking to develop new skills in these exciting areas. 

Contact: Douglas Phanstiel

E-mail: douglas_phanstiel@med.unc.edu

Phone: 608-609-8377


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Postdoc in Neuromodulation in Sensory Processing

Date Posted:
6/7/2018

Dacks Lab, West Virginia University

WV

LINK TO POST

Are you interested how your own physiological state affects how your brain processes information? We are recruiting 2 graduate students and a post-doc to join our lab at West Virginia University, for fall 2018.  We have several projects looking at the role of neuromodulation in sensory processing that take advantage of anatomical, molecular, physiological and behavioral approaches.

If you are interested, contact Dr. Andrew Dacks (andrew.dacks@mail.wvu.edu) and please include a resume or CV. Information about the Biology graduate program is at http://biology.wvu.edu/students/graduate-students.


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Postdoctoral Associate in Computational Biophysics/Chemistry

Date Posted:
6/7/2018

Filizola Lab, Icahn School of Medicine at Mount Sinai

NY

LINK TO POSTING

Applications are invited for a postdoc position in the Filizola Lab 
(http://www.filizolalab.org) at the Icahn School of Medicine at Mount Sinai,
 in New York City, USA. We are seeking highly qualified candidates with 
expertise and a strong publication record in the development and/or 
application of computational biophysics/chemistry tools, ranging from 
molecular dynamics simulations, enhanced sampling algorithms, free energy 
calculations, and machine learning approaches to investigate molecular 
mechanisms underlying protein function. This position will allow 
participation in a variety of interdisciplinary projects, offering an 
opportunity to work hand in hand with experimental collaborators. 

Ideal candidates would have a Ph.D. degree in Physics, Chemistry, Biophysics,
 Theoretical/Computational Chemistry, Chemical Engineering, or related 
discipline, and expert programming skills and analytical abilities in 
addition to a strong background in molecular dynamics simulation methods. 

Proven expertise in computational approaches for drug design (e.g., 
ligand-based and structure-based drug design, virtual screening, docking, 
pharmacophore analysis etc.) is a plus. Strong communication skills, and an 
ability to both collaborate with peers and/or train undergraduate students 
effectively are required. The position is available immediately.
Qualified applicants should send a CV and at least 2 reference names by 
email to Dr. Marta Filizola at marta.filizola_._mssm.edu. Review of 
applications will begin immediately and continue until position is filled.

NOTE THAT E-MAIL ADDRESSES HAVE BEEN MODIFIED!!!
All @ signs were changed to _._ to fight spam. Before you send e-mail, you need to change _._ to @
For example: change joe_._big123comp.com to joe@big123comp.com


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Postdoc(s) in Computational Genomics

Date Posted:
6/7/2018

Johns Hopkins University

MD

LINK TO POSTING

Johns Hopkins is a pretty amazing place to do computational genomics right now. My colleagues are really impressive, for example five of our faculty are part of the Chan Zuckerberg Initiative and we have faculty across a range of departments including Biostatistics, Computer Science, Biology, Biomedical Engineering, Human Genetics. A number of my colleagues are activitely looking for postdocs and in an effort to make the postdoc job market a little less opaque I’m listing this non-comprehensive list of opportunities I know about here.

Job: Postdoc(s) in methods development for precision medicine in oncology and immunotherapy (single cell RNA-seq, TCR sequencing).

Employer: Elana Fertig and Elizabeth Jaffee

To apply: email Elana

Deadline: Review ongoing

===============

Job: Timp lab is hiring postdocs! We work on sequencing technology and analysis development for direct RNA seq, epigenetics, cancer genomics, infectious disease diagnosis, non-model organism genomics, protein sequencing and all of the above!

Employer: Winston Timp

To apply: email Winston

Deadline: Until position filled

===============

Job: The Goff lab (www.gofflab.org) has 2 open postdoc positions for a variety of projects at the intersection of computational biology and neurodevelopment, degeneration, and disease. We develop and utilize single cell analysis techniques, including single cell RNA-Seq, to explore cell state transitions across continuous biological processes. Current funded projects include cross-model analysis of fALS, Parkinson Disease, and Kabuki Syndrome, as well as examination of cell-type-specific neuronal plasticity response, and developmental fate specification in the CNS.

Employer: Loyal Goff and Solange Brown

To apply: email Loyal

Deadline: 12/31/2018 or until position filled

===============

Job: The Hansen lab (www.hansenlab.org) is hiring postdocs in computational biology. We are funded to continue development of the recount2 (preprint) project, which involves joint processing, normalization, and analysis of all publicly available human RNA-seq samples. This project combines genomics with analysis of extremely large-scale RNA-seq data. The work is in collaboration with Jeff Leek, Ben Langmead and Alexis Battle at JHU.

Emplyer: Kasper D. Hansen

To apply: Email Kasper.

Deadline: Review ongoing

===============

Job: The Jaffe lab at the Lieber Institute for Brain Develpoment (affiliated with JHMI) is hiring at several different levels (research assistant, research associate, postdoc fellow)! We work at the intersection of genomics, biostatistics, and computational biology, leveraging large human brain datasets to better understand how genomic signatures associate with brain development and subsequent dysregulation in mental illness.

Employer: Andrew Jaffe

To apply: LIBD Careers

Deadline: Until position filled

===============

Job: The Battle lab (battlelab.jhu.edu) is hiring postdocs in genomics and machine learning/probabilistic modeling. Projects include rare genetic variation, single cell genomics, time series genomics, complex human disease, large scale integrative transcriptomic/eQTL studies, and more.

Employer: Alexis Battle

To apply: email Alexis

Deadline: Until positions filled


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Research Officer

Date Posted:
6/4/2018

Walter+Eliza Hall Institute of Medical Research

INT

Research Officer (Groom Laboratory)

 
Application closing date: 
Thu, 21/06/2018 - 5:00pm

About the position
Working across our Molecular Immunology and Immunology Divisions, this position will involve combining viral immunology, advanced imaging and bioinformatics analyses to determine the role of cell migration and interactions on T cell differentiation and memory response. This is an excellent opportunity for a creative postdoctoral scientist with demonstrated expertise in cellular and molecular immunology, mouse models and advanced imaging methods.

Responsibilities
The successful applicant will demonstrate innovation and planning when undertaking experimental design and recommending new approaches and techniques for assigned projects. This role will also involve continuous knowledge and skill acquisition through undertaking literature searches, identifying skill needs and attending appropriate meetings.In addition, you will be required to undertake advanced research procedures and operating advanced laboratory and technical equipment.

This role will involve taking initiative to independently solve problems, make substantial intellectual contributions in generating, analysing and interpreting data, along with producing research papers for publication. In addition, identifying opportunities to apply for salary support funding will be required.

Selection Criteria
To be considered for this role, the successful candidate will possess a relevant doctoral qualification or equivalent. This will be supported by an excellent academic record and achievements.

The successful candidate will have a proven track record in research publications, conference papers and reports. In addition to this, a demonstrated ability to collaborate and effectively communicate with others to achieve research outcomes will be required.

Terms of appointment
The position is available for a period of 12 months in the first instance. Up to 17% superannuation and very attractive salary packaging options are available.

A position description is available.

General Enquiries can be directed to Dr. Joanna Groom.

How to apply
Please email your application including cover letter, CV and a letter addressing the key selection criteria in pdf format to jobapplications@wehi.edu.au quoting reference WEHI/MKMI in the subject line.

At the Walter and Eliza Hall Institute we strive to ensure our staff and students enjoy a great working environment.  We value diversity and gender equity in our work force and promote flexible working arrangements for staff to balance working requirements and personal needs. We have implemented a number of gender equity initiatives to support female laboratory heads.


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Cardiovascular Disease - Cardiac Intermediate Filaments

Date Posted:
5/23/2018

Heart and Vascular Institute

MD

A post-doctoral fellowship position is AVAILABLE IMMEDIATELY at the Center for Research on Cardiac
Intermediate   Filaments   (CRCIF),   within   the   Johns   Hopkins   School   of   Medicine   
Institute   of Cardioscience:

http://www.hopkinsmedicine.org/heart_vascular_institute/research/by_laboratory/

The position is funded through a T32 training grant and therefore eligibility is limited to
green-card holders and citizens of the United States.

The general theme of research is centered on the interaction between cardiac intermediate filaments
(IFs) and mitochondria, in the setting of cardiovascular disease – the largest cause of
hospitalization and death in the U.S.

We recently published that desmin aggregates in the heart may act as amyloid aggregate observed in
Alzheimer’s and Parkinson’s diseases:

https://www.hopkinsmedicine.org/news/media/releases/heart_failure_the_alzheimers_disease_of_th
e_heart

The ideal candidate must be highly organized, proficient in English and interested in pursuing a
career in cardiovascular and muscle disease. A background in IFs biology is preferred and so is
technical competence in cell and molecular biology and protein biochemistry.

The successful candidate will be will be trained in protein biochemistry and proteomics as well as
mitochondrial biology. The project will span from basic research to clinical applications.

Johns Hopkins University is a competitive institution that provides for an exciting research
environment. The CRCIF is part of the Institute of Cardioscience, which along with the medical and
undergraduate campuses gives us access to a very broad set of expertise and many learning
opportunities.

Interested candidates should email an updated CV and the contacts of three references to Giulio
Agnetti at gagnett1@jhmi.edu.


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Kegan Lab – Vascular cell biology and lung physiology

Date Posted:
5/1/2018

Anesthesiology and Critical Care Medicine

MD

A postdoctoral position is available at the Johns Hopkins University School of Medicine, Department of Anesthesiology and Critical Care Medicine in the laboratory of Dr. Kazuyo Kegan, Ph.D. The overall focus of the Kegan lab is to understand the mechanisms, regulation, and functional outcomes of immune responses in the pulmonary vasculature during the development of pulmonary hypertension. To elucidate these mechanisms, fellows will use in vivo animal models, genetically modified animals, in vitro cell biology, immunohistochemistry, and genetic and biochemical approaches.

A successful candidate will use basic science approaches to address clinically relevant issues within a multidisciplinary team that includes clinician scientists and biomedical engineering groups.

Candidates should have a PhD degree (or equivalent) with a background in physiology, cell and molecular biology, biomedical science, or pharmacology. Individuals with experience in vascular/macrophage biology, immunology, or stem cell research will be given preference.

Please submit an application including a cover letter and CV that describes your research interests and accomplishments, and information for references (as a single PDF file) to Dr. Kegan at kkegan1@jhmi.edu .

 


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Han Lab - Computational Genetics

Date Posted:
4/23/2018

Psychiatry and Behavioral Sciences

MD

A postdoc position is now available to work with Dr. Shizhong Han, Associate Professor, in the Department of Psychiatry and Behavioral Sciences at Johns Hopkins.

Research in Dr. Han’s lab has been focused on investigating the genetic basis of psychiatric disorders, especially alcoholism and substance abuse. Another research focus is on developing statistical genetic approaches and computational tools that will facilitate the effort to identify disease susceptibility genes more broadly.

The candidate is expected to work with Dr. Han to develop and apply machine learning and network-based approaches to risk gene identification, disease risk prediction, and drug discovery for psychiatric disorders. Candidates with a doctoral degree in human genetics, bioinformatics, or other fields with strong quantitative skills (e.g., biostatistics, statistics, or computer science) will be considered.

Strong programing skills in Perl/Python and R are essential. Experiences with large-scale genetic or genomic datasets are necessary. Experiences with network-based approach or machine learning are a plus. The candidates need to be highly motivated, excellent in academic writing, and able to work well in a collaborative environment.

The successful candidate will receive intensive training on projects tailored to his/her research interests and experiences. The successful candidate will be encouraged to present research work in national and international meetings, and be supported for professional development.

Interested applicants should send curriculum vitae, statement of research interests, and contact information for three references to Shizhong Han at shan67@jhmi.edu

 


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