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Dr. Borahay Lab: Uterine fibroid research

Date Posted:
8/1/2018

Gynecology and Obstetrics

MD

Job Description:

This position is for a highly motivated postdoctoral research fellow to work on an exciting project in reproductive science at Johns Hopkins University at Baltimore, MD. The PI is Dr. Mostafa Borahay, MD, PhD and the project focuses on statins as a new treatment for uterine leiomyomas, the most common tumor of female reproductive system. Understanding the underlying pathogenesis of the tumor is another goal. Johns Hopkins University, the institution #1 in NIH funding for more than 30 years, provide an outstanding environment for state-of-the-art research for an ambitious fellow.

 The work will include cellular and extracellular matrix experiments of cell cultures (both conventional and 3D) from primary & immortalized cells.. It will also include tissues obtained from patients and animal models. In addition to standard cell culture, molecular biology, and histologic techniques, work will include experiments on stem cells and epigenetics.

 Work is funded by NIH grant and candidates for this position are expected to conduct research work in the current grant and preparation to apply for NIH funding early on. The fellow is expected to be self-motivated, organized, and team player.

 Responsibilities:

  • Critically review available literature and design research work accordingly.
  • Plans, conducts, and troubleshoots experiments.
  • Performs data analysis, prepares graphical representation of data, prepares manuscripts for publication in peer reviewed scientific journals, assists in the preparation of scientific reports for funded projects, presents research data at in-house meetings and at National and International scientific conferences.
  • Participates in preparation of applications for funding.
  • Participates on scientific collaborations both within and outside the institution as discussed with the PI.
  • Adopts technologies and protocols currently used in the lab and be able to research, find, and learn additional ones necessary for the work
  • Works as a team member with other faculty members, clinical research team, fellows, residents, and students.
  • Attends training and safety classes required by JHU
  • Completes other projects and duties as assigned.
  • Accurately documents experiments and results and keeps a detailed laboratory note.
  • Possesses good oral and written communication skills
  • Able to prioritize workload and manage multiple projects effectively.

 Required Knowledge, Skills, and Abilities:

Knowledge of complex scientific procedures and techniques; knowledge and practical experience in biophysical techniques, fundamental molecular and cellular biology and familiarity with biochemistry and cell culture, proliferation, cell death, protein science, Western Blotting, flow cytometry, RNA, DNA, sequencing, epigenetic (DNA methylation and histone modification) techniques. Candidate is expected to learn new techniques as necessary.

 Candidate is expected to demonstrate successful publication of doctoral work in reputable journals. Prior successful funding during doctoral work is a plus.

 Training and Career Development plan

This postdoctoral research fellowship program is designed to prepare the fellow for independent academic career in reproductive research. Focus will be scientific productivity demonstrated by innovative research, publication in high impact journals and successful extramural funding. Fellow is expected to transition in few years into an independent faculty role.

 Education: Ph.D. in Molecular Biology or cell biology

 Work Environment: Laboratory environment; requires working with human and animal cells/cell lines, blood, and or bodily fluids

 Supervisory Responsibilities/Controls: May provide guidance to laboratory staff and train junior staff members.

 Department/Division: Johns Hopkins University, School of Medicine, Department of Gynecology and Obstetrics. Division of Division of Reproductive Science and Women’s Health Research.

 To apply: Send CV and a cover letter/personal statement to PI: Mostafa Borahay, MD, PhD. Email: mboraha1@jhmi.edu


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Segars Lab: Non-classical nuclear hormone receptor signaling

Date Posted:
7/26/2018

Gynecology and Obstetrics

MD

GENERAL DESCRIPTION:

A 2-3 year postdoctoral fellowship position is available to study the molecular mechanisms coupling progesterone signaling and the extracellular matrix to downstream transcription factors that regulate gene transcription and growth of uterine leiomyoma. The goal is in to understand the mechanisms integrating the extracellular matrix with growth processes in this disease. We use a combination of tools, including, transfection, RNA-Seq and mouse genetics, to study the role of transcription factors in differentiation and human tissues.

Uterine leiomyomata, or fibroids, are benign, sex steroid hormone-dependent smooth muscle tumors that affect nearly 70% of Caucasian women and more than 80% of African American women by age 50. This position focuses on studying the molecular signaling and pathophysiology of uterine leiomyoma. The fellow will also participate in tissues derived from clinical trials based within the Department of Gynecology and Obstetrics.  The fellow will be involved in the design, conduct and analysis of the basic research and clinical translational experiments. The position provides a unique opportunity to learn and conduct research on basic, translational and clinical trial specimens and to work in an environment that encourages personal growth in the field of gynecological research (https://www.hopkinsmedicine.org/gynecology_obstetrics/research/).

Qualifications
Applicants should have a Ph.D. in endocrinology, reproductive biology or related discipline. Experience in transgenic mouse models and a strong background in molecular and cellular biology is desired. Excellent written, verbal, and interpersonal communication skills and fluency in both spoken and written English are essential. Demonstrated attention to detail, strong organizational skills, supervisory ability, and an innovative approach to experimental design. Computer literacy and working knowledge of software applications (word processing, spreadsheet, and database). Analytical ability sufficient to compare data; mathematical ability sufficient to perform algebraic calculations and statistical analysis. Ability to synthesize information and to create and deal with new situations by applying experiences. Expressed willingness to teach others and share results. Capable of meeting time demands necessary to execute experiments.

Application Instructions

Interested candidates should send a letter of interest, a CV, and contact information for three references to sng16@jhmi.edu. Applications will be evaluated on an ongoing basis until the position is filled. The starting date is flexible and available candidates could begin work immediately. However, we would like to fill the position no later than September 2018.


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Maheshwari Lab - Computational Genomics of Necrotizing Enterocolitis

Date Posted:
7/18/2018

Pediatrics

MD

A postdoctoral fellowship/research scientist position is available at Maheshwari laboratory of the Charlotte R. Bloomberg Children’s Center, Johns Hopkins University, Baltimore, MD. The individual will lead integrative computational genomics initiatives to characterize the mammalian genomic landscape and the enteric microbiome during necrotizing enterocolitis, which is an inflammatory bowel necrosis of premature infants. The candidate will also participate in the development of novel animal models to investigate neonatal intestinal injury. He/she will receive multidisciplinary training in or will be an active participant in projects combining computational genomics, integrative bioinformatics, molecular biology, and translational research. The candidate must hold a Ph.D. degree in the Biomedical Sciences or an advanced degree in bioinformatics. Preference will be given to highly-motivated candidates with an outstanding publication record in bioinformatics-based research, and those with established expertise in computational genomics, bioinformatics, or biostatistics.

The candidate will perform integrative analysis of deep-sequencing datasets of mammalian cells and 16S rRNA-based or whole genome sequencing for the gut microbiome. He/she will collaborate with other lab members who are focused on the development of animal and cellular models, and will also have opportunities to teach medical and bioscience trainees at various levels who might rotate through the lab.

Maheshwari laboratory is a translational research lab in the Department of Pediatrics at Johns Hopkins University, Baltimore. For more information, please send your CV, cover letter, and the contact information of 3 referees to:

 Akhil Maheshwari, M.D.

Professor of Pediatrics, PAR
?Director, Eudowood Division of Neonatology
?Vice-Chair (Integration), Department of Pediatrics
?Johns Hopkins University School of Medicine
??Office: The Charlotte R. Bloomberg Children’s Center / Room 8530
?   1800 Orleans Street
?   Baltimore, Maryland 21287
?   Email: akhil@jhmi.edu; Phone: 410-955-4574; Fax 410-955-0298


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