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Nagy Lab: Macrophage Specification and Contribution to Health and Disease

Date Posted:
4/8/2020

All Children's Hospital Institute for Fundamental Biomedical Research

FL

Position: Postdoctoral Research Fellow – Nagy Lab (Position 2)

Location: Johns Hopkins All Children’s Hospital, Institute for Fundamental Biomedical Research – St. Petersburg, FL

Laboratory Description: The Nagy research group is seeking highly motivated and enthusiastic postdoctoral fellows to contribute to their ongoing epigenomic, cell biological and in vivo analyses of the molecular basis of macrophage specification and contribution to health and disease. Come join this highly collaborative and interdisciplinary group.

Our laboratory utilizes diverse experimental techniques such as RNA-Seq, ChIP-Seq, ATAC-Seq, Hi-ChIP. HiC, lipidomics, bioinformatics and data integration and in vivo injury and disease models and has long-standing expertise in epigenomics, gene expression regulation, macrophage biology and skeletal muscle regeneration. We are part of a newly established highly interactive excellent research environment at Johns Hopkins All Children’s Hospital in St. Petersburg, Florida with strong ties to the Baltimore campus of Johns Hopkins University School of Medicine as being part of the Center for Metabolic Origins of Disease and the Metabolic Interest Group. In addition, the Nagy lab has an extensive network of collaborators throughout the US and in Europe allowing ample opportunity to travel and collaborate.

Our research projects involve epigenomics, macrophage polarization and subtype specification, tissue repair, Duchenne Muscle Dystrophy and acute and chronic inflammation. This allows exposure to diverse but overlapping areas of research. Much of our work has clinical and translational relevance.

Post-doctoral fellows in the Nagy Lab receive well-structured and extensive mentoring by the PI, are encouraged to initiate projects and collaborations, regularly get involved in reviewing and grant writing as well as supervising interns. Fellows are also encouraged to travel to learn new techniques, carry out collaborative research and attend national and international conferences. Former trainees of the lab have obtained positions at prestigious organizations: A. Szanto (MGH-Harvard), I. Szatmari (UT Southwestern), Sz. Benko (Univ. of Toronto), L. Szeles (Univ. of Geneva), D. Torocsik (Karolinska Inst.), M. Kiss (VIB, Brussels), Z. Simandi (UPenn), A. Horvath, (Australian National Univ.), B. Daniel (Stanford U.).

Position Description: Role of inflammation in disease progression and as a therapeutic target in skeletal muscle pathology (i.e. Duchenne Muscular Dystrophy and sarcopenia).

Required Experience: PhD with at least one first author publication in peer-reviewed journal(s). Experience with murine animal models is required. Experience in muscle physiology, histology, imaging and flow cytometry is a plus. Ability to work independently and as part of a team, excellent work ethic and being well organized.

Please contact Dr. Laszlo Nagy with questions or an application via email to lnagy@jhmi.edu with a CV and a name of three references.


Read the full job description

Nagy Lab: Macrophage Specification and Contribution to Health and Disease

Date Posted:
4/8/2020

All Children's Hospital Institute for Fundamental Biomedical Research

FL

Position: Postdoctoral Research Fellow – Nagy Lab (Position 1)

Location: Johns Hopkins All Children’s Hospital, Institute for Fundamental Biomedical Research – St. Petersburg, FL

Laboratory Description: The Nagy research group is seeking highly motivated and enthusiastic postdoctoral fellows to contribute to their ongoing epigenomic, cell biological and in vivo analyses of the molecular basis of macrophage specification and contribution to health and disease. Come join this highly collaborative and interdisciplinary group.

Our laboratory utilizes diverse experimental techniques such as RNA-Seq, ChIP-Seq, ATAC-Seq, Hi-ChIP. HiC, lipidomics, bioinformatics and data integration and in vivo injury and disease models and has long-standing expertise in epigenomics, gene expression regulation, macrophage biology and skeletal muscle regeneration. We are part of a newly established highly interactive excellent research environment at Johns Hopkins All Children’s Hospital in St. Petersburg, Florida with strong ties to the Baltimore campus of Johns Hopkins University School of Medicine as being part of the Center for Metabolic Origins of Disease and the Metabolic Interest Group. In addition, the Nagy lab has an extensive network of collaborators throughout the US and in Europe allowing ample opportunity to travel and collaborate.

Our research projects involve epigenomics, macrophage polarization and subtype specification, tissue repair, Duchenne Muscle Dystrophy and acute and chronic inflammation. This allows exposure to diverse but overlapping areas of research. Much of our work has clinical and translational relevance.

Post-doctoral fellows in the Nagy Lab receive well-structured and extensive mentoring by the PI, are encouraged to initiate projects and collaborations, regularly get involved in reviewing and grant writing as well as supervising interns. Fellows are also encouraged to travel to learn new techniques, carry out collaborative research and attend national and international conferences. Former trainees of the lab have obtained positions at prestigious organizations: A. Szanto (MGH-Harvard), I. Szatmari (UT Southwestern), Sz. Benko (Univ. of Toronto), L. Szeles (Univ. of Geneva), D. Torocsik (Karolinska Inst.), M. Kiss (VIB, Brussels), Z. Simandi (UPenn), A. Horvath, (Australian National Univ.), B. Daniel (Stanford U.).

Position Description: Transcriptional control of macrophage polarization: Study the mechanisms of interplay between transcription factor binding, enhancer activity and the 3D genome conformation.

Required Experience: PhD with at least one first author publication in peer-reviewed journal(s). Expertise in molecular biology is required. Experience in NGS techniques and bioinformatics is a plus. Ability to work independently and as part of a team, excellent work ethic and being well organized.

Please contact Dr. Laszlo Nagy with questions or an application via email to lnagy@jhmi.edu with a CV and a name of three references.


Read the full job description